Practical synthesis of methyl 7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)-heptanoate
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DOI: 10.1016/j.jscs.2017.01.004
Abstract: Abstract The key intermediate of misoprostol, methyl 7-(3-hydroxy-5-oxocyclopent-1-en-1-yl)-heptanoate was prepared from commercially available suberic acid in 40% yield over five steps. The key step involved a ZnCl 2 catalyzed Friedel-Crafts reaction between furan and 2,9-oxonanedione.… read more here.
Keywords: hydroxy oxocyclopent; oxocyclopent heptanoate; methyl hydroxy;