LAUSR

About LAUSR
Donate
Contact Us

Follow us:

You are not signed in:

Sign Up!


   Articles with "oxoglutarate dehydrogenase" as a keyword



Photo from wikipedia

Human 2-Oxoglutarate Dehydrogenase and 2-Oxoadipate Dehydrogenase Both Generate Superoxide/H2O2 in a Side Reaction and Each Could Contribute to Oxidative Stress in Mitochondria

Sign Up to like & get
recommendations! Published in 2019 at "Neurochemical Research"

DOI: 10.1007/s11064-019-02765-w

Abstract: According to recent findings, the human 2-oxoglutarate dehydrogenase complex (hOGDHc) could be an important source of the reactive oxygen species in the mitochondria and could contribute to mitochondrial abnormalities associated with multiple neurodegenerative diseases, including… read more here.

Keywords: dehydrogenase; oxoglutarate dehydrogenase; could contribute; human oxoglutarate ... See more keywords
Photo from wikipedia

Conformational transitions in the active site of mycobacterial 2-oxoglutarate dehydrogenase upon binding phosphonate analogues of 2-oxoglutarate: from a Michaelis-like complex to ThDP adducts.

Sign Up to like & get
recommendations! Published in 2019 at "Journal of structural biology"

DOI: 10.1016/j.jsb.2019.08.012

Abstract: Mycobacterial KGD, the thiamine diphosphate (ThDP)-dependent E1o component of the 2-oxoglutarate dehydrogenase complex (OGDHC), is known to undergo significant conformational changes during catalysis with two distinct conformational states, previously named as the early and late… read more here.

Keywords: thdp; oxoglutarate dehydrogenase; analogues oxoglutarate; phosphonate analogues ... See more keywords
Photo by fakurian from unsplash

Increasing Inhibition of the Rat Brain 2-Oxoglutarate Dehydrogenase Decreases Glutathione Redox State, Elevating Anxiety and Perturbing Stress Adaptation

Sign Up to like & get
recommendations! Published in 2022 at "Pharmaceuticals"

DOI: 10.3390/ph15020182

Abstract: Specific inhibitors of mitochondrial 2-oxoglutarate dehydrogenase (OGDH) are administered to animals to model the downregulation of the enzyme as observed in neurodegenerative diseases. Comparison of the effects of succinyl phosphonate (SP, 0.02 mmol/kg) and its… read more here.

Keywords: dehydrogenase; redox state; brain; rat brain ... See more keywords