Rational Engineering of the Nonheme Iron- and 2-Oxoglutarate-Dependent Oxygenase SptF.
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DOI: 10.1021/acs.orglett.2c00409
Abstract: The Fe- and 2-oxoglutarate-dependent oxygenase SptF is a promising powerful biocatalys with unusual catalytic versatility and promiscuity. The site-specific random substitution of N150, I63, and N65, which are involved in substrate interactions, generated three compounds… read more here.
Keywords: engineering; dependent oxygenase; oxoglutarate dependent; oxygenase sptf ... See more keywords
CanE, an Iron/2-Oxoglutarate-dependent Lasso Peptide Hydroxylase from Streptomyces canus.
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DOI: 10.1021/acschembio.0c00109
Abstract: Lasso peptides are a class of ribosomally-synthesized and post-translationally modified peptides (RiPPs) that feature a unique lariat-knot topology. Canucin A, a post-translationally hydroxylated lasso peptide, was recently discovered via activation of its otherwise silent biosynthetic… read more here.
Keywords: streptomyces canus; iron oxoglutarate; oxoglutarate dependent; lasso peptide ... See more keywords
A 2-Oxoglutarate-Dependent Dioxygenase Mediates the Biosynthesis of Glucoraphasatin in Radish1[OPEN]
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DOI: 10.1104/pp.16.01814
Abstract: Biosynthesis of glucoraphasatin, a major glucosinolate in radish, is mediated by 2-oxoglutarate-dependent dioxygenase. Glucosinolates (GSLs) are secondary metabolites whose degradation products confer intrinsic flavors and aromas to Brassicaceae vegetables. Several structures of GSLs are known… read more here.
Keywords: biosynthesis; glucoraphasatin; oxoglutarate dependent; dependent dioxygenase ... See more keywords
2-oxoglutarate-dependent dioxygenases: A renaissance in attention for ascorbic acid in plants
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DOI: 10.1371/journal.pone.0242833
Abstract: L-Ascorbic acid (ascorbate, Vitamin C) is an essential human micronutrient that is predominantly obtained from plants. It is known to work as the major antioxidant in plants, and it underpins several environmentally induced stresses due… read more here.
Keywords: dependent dioxygenases; oxoglutarate dependent; dioxygenases renaissance; ascorbic acid ... See more keywords