Bi-allelic Mutations in the Mitochondrial Ribosomal Protein MRPS2 Cause Sensorineural Hearing Loss, Hypoglycemia, and Multiple OXPHOS Complex Deficiencies.
Sign Up to like & getrecommendations! Published in 2018 at "American journal of human genetics"
DOI: 10.1016/j.ajhg.2018.02.012
Abstract: Biogenesis of the mitochondrial oxidative phosphorylation system, which produces the bulk of ATP for almost all eukaryotic cells, depends on the translation of 13 mtDNA-encoded polypeptides by mitochondria-specific ribosomes in the mitochondrial matrix. These mitoribosomes… read more here.
Keywords: multiple oxphos; sensorineural hearing; hypoglycemia; oxphos ... See more keywords
Automated quantitative high-throughput multiplex immunofluorescence pipeline to evaluate OXPHOS defects in formalin-fixed human prostate tissue
Sign Up to like & getrecommendations! Published in 2022 at "Scientific Reports"
DOI: 10.1038/s41598-022-10588-z
Abstract: Advances in multiplex immunofluorescence (mIF) and digital image analysis has enabled simultaneous assessment of protein defects in electron transport chain components. However, current manual methodology is time consuming and labour intensive. Therefore, we developed an… read more here.
Keywords: methodology; prostate; oxphos; multiplex immunofluorescence ... See more keywords
Coordinating mitochondrial translation with assembly of the OXPHOS complexes
Sign Up to like & getrecommendations! Published in 2024 at "Human Molecular Genetics"
DOI: 10.1093/hmg/ddae025
Abstract: Abstract The mitochondrial oxidative phosphorylation (OXPHOS) system produces the majority of energy required by cells. Given the mitochondrion’s endosymbiotic origin, the OXPHOS machinery is still under dual genetic control where most OXPHOS subunits are encoded… read more here.
Keywords: coordinating mitochondrial; assembly oxphos; translation; oxphos ... See more keywords
Two Weeks of Nrf2 Activation Improves Maximal Mitochondrial Respiration in Older Adults with Lower Starting Values
Sign Up to like & getrecommendations! Published in 2023 at "Physiology"
DOI: 10.1152/physiol.2023.38.s1.5733812
Abstract: Background: The impact of aging on skeletal muscle mitochondrial function, as assessed by maximal mitochondrial respiration (OXPHOS), is a developing field of research with no clear consensus. Older individuals often display a greater range of… read more here.
Keywords: oxphos; pmol; physiology; older individuals ... See more keywords
Proteomics reveals COX7B as a prognostically relevant oxphos-linked protein in pediatric AML
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DOI: 10.1182/blood-2025-5277
Abstract: Introduction: Acute myeloid leukemia (AML) is a complex and highly heterogeneous hematologic malignancy with poor clinical outcomes. Despite improvements in supportive care, the standard treatment for AML has remained largely unchanged since the 1970s through… read more here.
Keywords: survival; prognosis; aml; protein ... See more keywords
1824-P: Bioenergetic Advantage of Pyruvate Kinase Overcomes Mitochondrial OXPHOS in Beta-Cells to Initiate Insulin Secretion
Sign Up to like & getrecommendations! Published in 2025 at "Diabetes"
DOI: 10.2337/db25-1824-p
Abstract: Introduction and Objective: The high relative free energy of phosphoenolpyruvate (PEP) positions pyruvate kinase (PK) as the driver of insulin secretion in beta-cells by increasing the ATP/ADP ratio and closing KATP channels. In this model,… read more here.
Keywords: insulin secretion; pyruvate kinase; oxphos; beta cells ... See more keywords
Lack of transcriptional coordination between mitochondrial and nuclear oxidative phosphorylation genes in the presence of two divergent mitochondrial genomes
Sign Up to like & getrecommendations! Published in 2022 at "Zoological Research"
DOI: 10.24272/j.issn.2095-8137.2021.348
Abstract: In most eukaryotes, oxidative phosphorylation (OXPHOS) is the main energy production process and it involves both mitochondrial and nuclear genomes. The close interaction between the two genomes is critical for the coordinated function of the… read more here.
Keywords: oxphos; oxphos genes; nuclear oxphos; mitochondrial genomes ... See more keywords
Negative Selection in Oreochromis niloticus × O. aureus Hybrids Indicates Incompatible Oxidative Phosphorylation (OXPHOS) Proteins
Sign Up to like & getrecommendations! Published in 2025 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms26052089
Abstract: Crossing Oreochromis niloticus (On) females with O. aureus (Oa) males results in all-male progeny that are essential for effective tilapia aquaculture. However, a reproductive barrier between these species prevents commercial-scale yield. To achieve all-male progeny,… read more here.
Keywords: oxidative phosphorylation; oreochromis niloticus; phosphorylation oxphos; selection ... See more keywords