NNMT‐DNMT1 Axis is Essential for Maintaining Cancer Cell Sensitivity to Oxidative Phosphorylation Inhibition
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DOI: 10.1002/advs.202202642
Abstract: Lacking a clear understanding of the molecular mechanism determining cancer cell sensitivity to oxidative phosphorylation (OXPHOS) inhibition limits the development of OXPHOS‐targeting cancer treatment. Here, cancer cell lines sensitive or resistant to OXPHOS inhibition are… read more here.
Keywords: inhibition; sensitivity; oxphos inhibition; cancer cell ... See more keywords
PO-017 Androgen deprivation and oxidative phosporylation inhibition pose synergistic antitumor effects in subsets of prostate tumours in vitro
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DOI: 10.1136/esmoopen-2018-eacr25.552
Abstract: Introduction Cancer cells are able to survive oxidative phosphorylation (OXPHOS) inhibition by up-regulation of glycolysis. Androgens stimulate glycolysis in prostate cancer cells through activation of the androgen receptor (AR). Here we hypothesise that androgens might… read more here.
Keywords: cell viability; oxphos inhibition; addition; lncap cells ... See more keywords
Abstract 3687: Disruption of nucleotide homeostasis confers cancer cell susceptibility to oxidative phosphorylation inhibition independently of energy depletion
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DOI: 10.1158/1538-7445.am2023-3687
Abstract: Cancer metabolism is highly heterogenous and flexible with the Warburg effect or oxidative phosphorylation (OXPHOS) prevailing in a cancer type- and context-dependent manner. Past studies have demonstrated that targeting OXPHOS robustly inhibits glycolysis-deficient cancer cell… read more here.
Keywords: cell; oxphos inhibition; cancer cell; cell susceptibility ... See more keywords