UFC1 reveals the multifactorial and plastic nature of oxyanion holes in E2 conjugating enzymes
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DOI: 10.1038/s41467-025-58826-y
Abstract: The conjugation of ubiquitin (Ub) or ubiquitin-like proteins (UBL) to target proteins is a crucial post-translational modification that typically involves nucleophilic attack by a lysine on a charged E2 enzyme (E2~Ub/UBL), forming an oxyanion intermediate.… read more here.
Keywords: ufc1 reveals; oxyanion; oxyanion holes; oxyanion intermediate ... See more keywords