501 Clinical PK of XW10172 for Once Nightly Therapy in Patients with Narcolepsy or Sleep Disorders in Neurodegenerative Diseases
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DOI: 10.1093/sleep/zsab072.500
Abstract: Patients with narcolepsy and patients with sleep disorders secondary to neurodegenerative diseases have been shown to respond to oxybate. To overcome the limitations of current oxybate therapies, we designed XW10172, a new chemical entity and… read more here.
Keywords: oxybate; sleep disorders; 501 clinical; xw10172 ... See more keywords
0411 Once-Nightly Sodium Oxybate Dose Titration and Tolerability: Interim Data From RESTORE
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DOI: 10.1093/sleep/zsac079.408
Abstract: Extended-release, once-nightly sodium oxybate (ON-SXB; FT218) is under FDA review for the treatment of adults with narcolepsy. RESTORE, an ongoing, open-label extension/switch study (NCT04451668), evaluates long-term ON-SXB safety and tolerability. This interim analysis assessed dosing… read more here.
Keywords: titration; tolerability; oxybate; group ... See more keywords
0579 Long-Term Safety of Once-Nightly Oxybate for Narcolepsy: RESTORE Study Interim Analysis of Data
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DOI: 10.1093/sleep/zsad077.0579
Abstract: The pivotal phase 3 REST-ON trial (NCT02720744) evaluated the efficacy and safety of once-nightly sodium oxybate (ON-SXB; FT218), an investigational extended-release formulation for treatment of adults with narcolepsy. In REST-ON, ON-SXB met its 3 coprimary… read more here.
Keywords: safety; oxybate; sxb; restore study ... See more keywords
0584 Sodium Oxybate Treatment Patterns in Narcolepsy Patients: A Propensity Score–Matched Cohort Study Subanalysis
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DOI: 10.1093/sleep/zsad077.0584
Abstract: Sodium oxybate (SXB) is strongly recommended for treatment of narcolepsy. Patients treated with available immediate-release oxybates are required to awaken for a second dose 2.5–4 hours after the bedtime dose to cover a full night… read more here.
Keywords: second dose; oxybate; narcolepsy patients; discontinuation ... See more keywords
0985 Oxybate induced mania
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DOI: 10.1093/sleep/zsad077.0985
Abstract: Hypersomnia sleep disorders are characterized by overwhelming daytime sleepiness. Treatment options include sodium oxybate the sodium salt of γ-hydroxybutyric acid (GHB). Oxybate, an endogenous metabolite of GABA, acts through GABAB noradrenergic and dopaminergic neurons, as… read more here.
Keywords: hypersomnia; oxybate; sodium oxybate; mania ... See more keywords