Intravesical oxybutynin therapy for patients with neurogenic detrusor overactivity: a systematic review and meta-analysis
Sign Up to like & getrecommendations! Published in 2022 at "International Urology and Nephrology"
DOI: 10.1007/s11255-022-03129-0
Abstract: To evaluate the effectiveness and safety of intravesical oxybutynin therapy for patients with neurogenic detrusor overactivity. A systematic search in PubMed, MEDLINE, EMBASE, ClinicalTrial.gov, and Cochrane Controlled Trials Register was conducted from 1990 to 2021.… read more here.
Keywords: oxybutynin; intravesical oxybutynin; detrusor overactivity; neurogenic detrusor ... See more keywords
First-in-human study to assess the pharmacokinetics, tolerability, and safety of single-dose oxybutynin hydrochloride administered via a microprocessor-controlled intravaginal ring
Sign Up to like & getrecommendations! Published in 2023 at "Drug Delivery"
DOI: 10.1080/10717544.2023.2180113
Abstract: Abstract Polymeric drug-releasing vaginal rings are useful for both local and systemic administration of drugs via the intravaginal route. Typically, they provide continuous sustained or controlled release of drug(s) over extended time periods, thereby avoiding… read more here.
Keywords: oxybutynin; oxybutynin hydrochloride; human study; dose oxybutynin ... See more keywords
The anticholinergic drug oxybutynin inhibits voltage‐dependent K+ channels in coronary arterial smooth muscle cells
Sign Up to like & getrecommendations! Published in 2019 at "Clinical and Experimental Pharmacology and Physiology"
DOI: 10.1111/1440-1681.13138
Abstract: This study demonstrates the inhibitory effect of anticholinergic drug oxybutynin on voltage‐dependent K+ (Kv) channels in rabbit coronary arterial smooth muscle cells. Oxybutynin inhibited vascular Kv channels in a concentration‐dependent manner, with an IC50 value… read more here.
Keywords: oxybutynin; voltage dependent; dependent channels; anticholinergic drug ... See more keywords
Oxybutynin gel versus nanoemulgel for treating primary palmar hyperhidrosis: A pilot double-blind randomized controlled trial.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of cosmetic dermatology"
DOI: 10.1111/jocd.15715
Abstract: INTRODUCTION Palmar hyperhidrosis or excessive palmar sweating can reduce one's quality of life as it is associated with significant physical and occupational disabilities. We compared the gel and nanoemulgel of oxybutynin in treating these patients.… read more here.
Keywords: oxybutynin; palmar hyperhidrosis; dermatology; gel ... See more keywords
The Combination of Atomoxetine and Oxybutynin Greatly Reduces Obstructive Sleep Apnea Severity. A Randomized, Placebo-controlled, Double-Blind Crossover Trial.
Sign Up to like & getrecommendations! Published in 2019 at "American journal of respiratory and critical care medicine"
DOI: 10.1164/rccm.201808-1493oc
Abstract: Rationale: There is currently no effective pharmacological treatment for obstructive sleep apnea (OSA). Recent investigations indicate that drugs with noradrenergic and antimuscarinic effects improve genioglossus muscle activity and upper airway patency during sleep. Objectives: We… read more here.
Keywords: placebo; oxybutynin; severity; obstructive sleep ... See more keywords