Establishment to measure oxycodone in plasma with liquid chromatography–tandem mass spectrometry
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DOI: 10.1002/npr2.12268
Abstract: Oxycodone (OXY) is classified as a “strong opioid” in the World Health Organization system of cancer pain treatment. However, OXY also causes severe adverse reactions, such as respiratory depression. Thus, in order to adjust the… read more here.
Keywords: chromatography tandem; tandem mass; liquid chromatography; mass spectrometry ... See more keywords
Oxycodone stimulates normal and malignant hematopoietic progenitors via opioid-receptor-independent-β-catenin activation.
Sign Up to like & getrecommendations! Published in 2020 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2020.10.031
Abstract: Oxycodone is a common type of opioid used for the treatment of moderate to severe pain. Besides its analgesic effects on neuron cells, the effects of oxycodone on other cell types are yet to be… read more here.
Keywords: catenin; activation; receptor; stem ... See more keywords
In a Rat Model of Opioid Maintenance, the G Protein–Biased Mu Opioid Receptor Agonist TRV130 Decreases Relapse to Oxycodone Seeking and Taking and Prevents Oxycodone-Induced Brain Hypoxia
Sign Up to like & getrecommendations! Published in 2020 at "Biological Psychiatry"
DOI: 10.1016/j.biopsych.2020.02.014
Abstract: BACKGROUND Maintenance treatment with opioid agonists (buprenorphine, methadone) is effective for opioid addiction but does not eliminate opioid use in all patients. We modeled maintenance treatment in rats that self-administered the prescription opioid oxycodone. The… read more here.
Keywords: oxycodone seeking; protein biased; maintenance; biased opioid ... See more keywords
Delta‐opioid receptor antagonist naltrindole reduces oxycodone addiction and constipation in mice
Sign Up to like & getrecommendations! Published in 2019 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2019.04.009
Abstract: ABSTRACT Oxycodone, a widely prescribed and very potent oral opioid analgesic agent, is highly addictive and has many side effects, including troublesome constipation. Our studies in mice indicated that pretreatment of naltrindole did not significantly… read more here.
Keywords: opioid receptor; mice; delta opioid; constipation ... See more keywords
Nalfurafine modulates the reinforcing effects of oxycodone in male and female adolescent C57BL/6J mice
Sign Up to like & getrecommendations! Published in 2020 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2020.108244
Abstract: Addiction to prescription opioid, such as oxycodone, has affected millions of adolescents and young adults. Kappa opioid receptor (KOP-r) agonist can counterbalance the euphoria effects of mu opioid agonists like oxycodone. Nalfurafine is a KOP-r… read more here.
Keywords: nalfurafine; male female; mice; female adolescent ... See more keywords
Pharmacological mechanisms underlying the efficacy of antibodies generated by a vaccine to treat oxycodone use disorder
Sign Up to like & getrecommendations! Published in 2021 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108653
Abstract: Therapeutic vaccines offer a viable strategy to treat opioid use disorders (OUD) complementary to current pharmacotherapies. The candidate Oxy(Gly)4-sKLH vaccine targeting oxycodone displayed pre-clinical proof of efficacy, selectivity and safety, and it is now undergoing… read more here.
Keywords: treat; gly sklh; efficacy; vaccination ... See more keywords
A limited access oral oxycodone paradigm produces physical dependence and mesocorticolimbic region-dependent increases in DeltaFosB expression without preference
Sign Up to like & getrecommendations! Published in 2022 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2021.108925
Abstract: The abuse of oral formulations of prescription opioids has precipitated the current opioid epidemic. We developed an oral oxycodone consumption model consisting of a limited access (4 h) two-bottle choice drinking in the dark (TBC-DID) paradigm… read more here.
Keywords: oxycodone; preference; dependence; oral oxycodone ... See more keywords
Combined HIV-1 Tat and oxycodone activate the hypothalamic-pituitary-adrenal and -gonadal axes and promote psychomotor, affective, and cognitive dysfunction in female mice
Sign Up to like & getrecommendations! Published in 2020 at "Hormones and Behavior"
DOI: 10.1016/j.yhbeh.2019.104649
Abstract: The majority of HIV+ patients present with neuroendocrine dysfunction and ~50% experience co-morbid neurological symptoms including motor, affective, and cognitive dysfunction, collectively termed neuroHIV. In preclinical models, the neurotoxic HIV-1 regulatory protein, trans-activator of transcription… read more here.
Keywords: dysfunction; pathology; mice; hiv tat ... See more keywords
Electrochemical Detection of Oxycodone and Its Main Metabolites with Nafion-Coated Single-Walled Carbon Nanotube Electrodes
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DOI: 10.1021/acs.analchem.0c00450
Abstract: Oxycodone is a strong opioid frequently used as an analgesic. Although proven efficacious in the management of moderate to severe acute pain and cancer pain, use of oxycodone imposes a risk of adverse effects such… read more here.
Keywords: swcnt; nafion; walled carbon; single walled ... See more keywords
A Quality Improvement Effort to Reduce Inpatient Opioid Consumption following Cesarean Delivery.
Sign Up to like & getrecommendations! Published in 2022 at "American journal of perinatology"
DOI: 10.1055/a-1884-1155
Abstract: OBJECTIVE The amount of opioid prescribed following cesarean delivery is commonly in excess of patients' needs. An additional concern in a breastfeeding mother is neonatal opioid exposure. A maximum daily dose of 30 mg of… read more here.
Keywords: opioid consumption; cesarean delivery; pain; oxycodone ... See more keywords
"Pressed OXY M30 Pills, Great Press, Potent, Fast Shipping!!!": Availability of Counterfeit and Pharmaceutical Oxycodone Pills on One Major Cryptomarket.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of psychoactive drugs"
DOI: 10.1080/02791072.2023.2176954
Abstract: From 2018 to 2021, seizures of counterfeit oxycodone pills containing non-pharmaceutical fentanyl or other novel synthetic opioids increased significantly contributing to continuing increases in overdose mortality in Northern America. Evidence suggests that counterfeit pills are… read more here.
Keywords: counterfeit pharmaceutical; oxycodone pills; availability; oxycodone ... See more keywords