Can early oral prolonged-release oxycodone with or without naloxone reduce the duration of epidural analgesia after cystectomy? A 3-arm, randomized, double-blind, placebo-controlled trial
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DOI: 10.1097/j.pain.0000000000001112
Abstract: Abstract Thoracic epidural analgesia (TEA) enhances recovery after bowel surgery. Early postoperative prolonged-release oral formulation of oxycodone or oxycodone/naloxone is potentially useful as a second analgesic step to reduce the duration of TEA. We hypothesized… read more here.
Keywords: group; duration; oxycodone naloxone; placebo ... See more keywords
Combatting pain after orthopedic/trauma surgery- perioperative oral extended-release tapentadol vs. extended-release oxycodone/naloxone
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DOI: 10.1186/s12871-017-0383-6
Abstract: BackgroundHigh post-operative pain scores after “minor” orthopedic/trauma surgery are in part attributed to inadequate prescription of opioid analgesics. Novel concepts aiming to achieve sufficient analgesia while minimizing opioid-related side effects by avoiding fluctuating plasma levels… read more here.
Keywords: surgery; extended release; tapentadol; trauma ... See more keywords
Factors influencing the analgesic response over time of the oxycodone-naloxone association in painful cancer patients: GREAT study.
Sign Up to like & getrecommendations! Published in 2017 at "Journal of Clinical Oncology"
DOI: 10.1200/jco.2017.35.15_suppl.10089
Abstract: 10089Background: The prolonged use of opioids is usually associated with the appearance of adverse events as drowsiness, constipation, nausea/vomiting, and dizziness. Some effects are self-limiting... read more here.
Keywords: influencing analgesic; analgesic response; time oxycodone; oxycodone naloxone ... See more keywords
Oxycodone-Naloxone Combination Hinders Opioid Consumption in Osteoarthritic Chronic Low Back Pain: A Retrospective Study with Two Years of Follow-Up
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DOI: 10.3390/ijerph192013354
Abstract: Chronic low back pain (CLBP) due to osteoarthritis represents a therapeutic challenge worldwide. Opioids are extensively used to treat such pain, but the development of tolerance, i.e., less susceptibility to the effects of the opioid,… read more here.
Keywords: oxycodone naloxone; chronic low; pain; low back ... See more keywords
Analgesic Efficacy and Safety of Prolonged-Release Oxycodone/Naloxone in Korean Patients with Chronic Pain from Spinal Disorders
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DOI: 10.4055/cios.2018.10.1.33
Abstract: Background A prolonged-release formulation of oxycodone/naloxone has been shown to be effective in European populations for the management of chronic moderate to severe pain. However, no clinical data exist for its use in Korean patients.… read more here.
Keywords: prolonged release; korean patients; release oxycodone; oxycodone naloxone ... See more keywords
Adverse effects of modified release oxycodone/naloxone in patients with moderate to severe liver impairment
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DOI: 10.5694/mja18.00380
Abstract: MR-oxycodone/naloxone is an oral combination opioid analgesic. The naloxone component is subject to a significant first-pass metabolism, and bioavailability is less than 2%. The benefit of low level oral bioavailability of naloxone is reducedopioid-induced constipationdue… read more here.
Keywords: effects modified; oxycodone naloxone; adverse effects; modified release ... See more keywords