In a Rat Model of Opioid Maintenance, the G Protein–Biased Mu Opioid Receptor Agonist TRV130 Decreases Relapse to Oxycodone Seeking and Taking and Prevents Oxycodone-Induced Brain Hypoxia
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DOI: 10.1016/j.biopsych.2020.02.014
Abstract: BACKGROUND Maintenance treatment with opioid agonists (buprenorphine, methadone) is effective for opioid addiction but does not eliminate opioid use in all patients. We modeled maintenance treatment in rats that self-administered the prescription opioid oxycodone. The… read more here.
Keywords: oxycodone seeking; protein biased; maintenance; biased opioid ... See more keywords
Fos‐expressing neuronal ensembles in rat infralimbic cortex encode initial and maintained oxycodone seeking in rats
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DOI: 10.1111/adb.13148
Abstract: Neuronal ensembles within the infralimbic cortex (IL) and their projections to the nucleus accumbens (NAc) mediate opiate seeking in well‐trained rats. However, it is unclear how early this circuitry is recruited during oxycodone self‐administration. Here,… read more here.
Keywords: self administration; neuronal ensembles; infralimbic cortex; oxycodone self ... See more keywords
Neuropathic pain has sex‐specific effects on oxycodone‐seeking and non‐drug‐seeking ensemble neurons in the dorsomedial prefrontal cortex of mice
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DOI: 10.1111/adb.13430
Abstract: Approximately 50 million Americans suffer from chronic pain, and nearly a quarter of chronic pain patients have reported misusing opioid prescriptions. Repeated drug seeking is associated with reactivation of an ensemble of neurons sparsely scattered… read more here.
Keywords: pain; chronic pain; drug; ensemble neurons ... See more keywords
Role of mu, but not delta or kappa, opioid receptors in context‐induced reinstatement of oxycodone seeking
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DOI: 10.1111/ejn.13955
Abstract: Relapse to non‐medical use of prescription opioids often occurs after exposure to places previously associated with drug use. Here, we describe a rat model of context‐induced reinstatement of oxycodone seeking after repeated cycles of drug… read more here.
Keywords: reinstatement; oxycodone seeking; reinstatement oxycodone; context induced ... See more keywords