Effects of lorcaserin on oxycodone self-administration and subjective responses in participants with opioid use disorder.
Sign Up to like & getrecommendations! Published in 2020 at "Drug and alcohol dependence"
DOI: 10.1016/j.drugalcdep.2020.107859
Abstract: BACKGROUND Lorcaserin, a high-affinity 5-HT2C receptor agonist approved for treating obesity, decreased self-administration of oxycodone and cue-induced reinstatement of drug-seeking behavior in preclinical studies. The current investigation is the first clinical trial to evaluate the… read more here.
Keywords: self administration; administration; oxycodone self; opioid use ... See more keywords
Repeated blast mild traumatic brain injury and oxycodone self‐administration produce interactive effects on neuroimaging outcomes
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DOI: 10.1111/adb.13134
Abstract: Traumatic brain injury (TBI) and drug addiction are common comorbidities, but it is unknown if the neurological sequelae of TBI contribute to this relationship. We have previously reported elevated oxycodone seeking after drug self‐administration in… read more here.
Keywords: self administration; oxycodone self; interactive effects; injury ... See more keywords
Fos‐expressing neuronal ensembles in rat infralimbic cortex encode initial and maintained oxycodone seeking in rats
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DOI: 10.1111/adb.13148
Abstract: Neuronal ensembles within the infralimbic cortex (IL) and their projections to the nucleus accumbens (NAc) mediate opiate seeking in well‐trained rats. However, it is unclear how early this circuitry is recruited during oxycodone self‐administration. Here,… read more here.
Keywords: self administration; neuronal ensembles; infralimbic cortex; oxycodone self ... See more keywords
Oral oxycodone self‐administration leads to features of opioid misuse in male and female mice
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DOI: 10.1111/adb.13253
Abstract: Use of prescription opioids, particularly oxycodone, is an initiating factor driving the current opioid epidemic. There are several challenges with modelling oxycodone abuse. First, prescription opioids including oxycodone are orally self‐administered and have different pharmacokinetics… read more here.
Keywords: self administration; administration; prescription opioid; oxycodone self ... See more keywords
Incubation of Oxycodone Craving Following Adult-Onset and Adolescent-Onset Oxycodone Self-Administration in Male Rats
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2021.697509
Abstract: Relapse is a major obstacle to curb the ongoing epidemic of prescription opioid abuse. We and others previously demonstrated that oxycodone seeking in adult rats progressively increases after abstinence from oxycodone self-administration (incubation of oxycodone… read more here.
Keywords: self administration; adult; oxycodone craving; oxycodone self ... See more keywords
Ranking the contribution of behavioral measures comprising oxycodone self-administration to reinstatement of drug-seeking in male and female rats
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Behavioral Neuroscience"
DOI: 10.3389/fnbeh.2022.1035350
Abstract: Introduction Rates of relapse to drug use during abstinence are among the highest for opioid use disorder (OUD). In preclinical studies, reinstatement to drug-seeking has been extensively studied as a model of relapse–but the work… read more here.
Keywords: self administration; female rats; administration; oxycodone self ... See more keywords
Suvorexant, an FDA-approved dual orexin receptor antagonist, reduces oxycodone self-administration and conditioned reinstatement in male and female rats
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1127735
Abstract: Background: The Department of Health and Human Services reports that prescription pain reliever (e.g., oxycodone) misuse was initiated by 4,400 Americans each day in 2019. Amid the opioid crisis, effective strategies to prevent and treat… read more here.
Keywords: self administration; oxycodone self; receptor antagonist; administration ... See more keywords
Escalated (Dependent) Oxycodone Self-Administration Is Associated with Cognitive Impairment and Transcriptional Evidence of Neurodegeneration in Human Immunodeficiency Virus (HIV) Transgenic Rats
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DOI: 10.3390/v14040669
Abstract: Substance use disorder is associated with accelerated disease progression in people with human immunodeficiency virus (HIV; PWH). Problem opioid use, including high-dose opioid therapy, prescription drug misuse, and opioid abuse, is high and increasing in… read more here.
Keywords: self administration; hiv; oxycodone self; transcriptional evidence ... See more keywords