How we diagnose and manage altered oxygen affinity hemoglobin variants: Lest we forget JAK2 Exon 12 mutation
Sign Up to like & getrecommendations! Published in 2019 at "American Journal of Hematology"
DOI: 10.1002/ajh.25559
Abstract: that her persistent thrombocytopenia was caused by sepsis, not refractory TTP. In Patient 10, TTP was unresponsive to multiple treatments, in addition to PEX, corticosteroids, and rituximab. Plus, ADAMTS13 activity was not measured during her… read more here.
Keywords: manage altered; oxygen affinity; hemoglobin variants; diagnose manage ... See more keywords
Novel, de novo, beta‐globin variant with decreased oxygen affinity (HBB:c.317T>A, “Hemoglobin St. George”) in a healthy child with low oxygen saturations and anemia
Sign Up to like & getrecommendations! Published in 2021 at "American Journal of Hematology"
DOI: 10.1002/ajh.26356
Abstract: To the Editor: Low oxygen affinity hemoglobin (Hb) mutations are a rare but important consideration in patients presenting with low peripheral oxygen saturations (SpO2) and anemia without clinical evidence of hypoxia; cyanosis may also be… read more here.
Keywords: oxygen; globin; hematology; oxygen affinity ... See more keywords
Hemoglobin Oxygen Affinity Does Not Change in the Canine Model of Moderate Acute Normovolemic Hemodilution
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DOI: 10.1021/acsomega.5c05248
Abstract: Objective: As the amount of hemoglobin (Hb) decreases during moderate acute normovolemic hemodilution (ANH), it is unclear whether the Hb-oxygen affinity (HOA) changes accordingly. Thus, this study aimed to explore changes in HOA during moderate… read more here.
Keywords: acute normovolemic; moderate acute; oxygen; oxygen affinity ... See more keywords
The unique allosteric property of crocodilian haemoglobin elucidated by cryo-EM
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DOI: 10.1038/s41467-024-49947-x
Abstract: The principal effect controlling the oxygen affinity of vertebrate haemoglobins (Hbs) is the allosteric switch between R and T forms with relatively high and low oxygen affinity respectively. Uniquely among jawed vertebrates, crocodilians possess Hb… read more here.
Keywords: oxygen; unique allosteric; oxygen affinity; property ... See more keywords
Hb Bakersfield (HBA1: c.151_152insGGAGCC): The Insertion of Arg-His Between Codons 49 and 50 of the α1-Globin Chain Leads to Increased Oxygen Affinity
Sign Up to like & getrecommendations! Published in 2017 at "Hemoglobin"
DOI: 10.1080/03630269.2017.1302467
Abstract: Abstract We describe an insertion variant on the α1-globin gene (HBA1) identified in a 49-year-old woman of Jurassian ancestry presenting with macrocytosis and erythrocytosis. The variant resulted in a peak of 15.5% of the total… read more here.
Keywords: oxygen; hba1 151; oxygen affinity; 151 152insggagcc ... See more keywords
Hemoglobin J-Auckland: a clinically silent low oxygen affinity variant presenting with persistent asymptomatic hypoxemia at high altitude
Sign Up to like & getrecommendations! Published in 2024 at "Hematology"
DOI: 10.1080/16078454.2024.2405751
Abstract: ABSTRACT Background Inherited hemoglobin disorders are common in clinical practice. While qualitative (i.e. sickle cell disease) and quantitative (thalassemia) hemoglobinopathies are usually diagnosed clinically and confirmed through simple laboratory assessments, hemoglobin variants with altered oxygen… read more here.
Keywords: hemoglobin auckland; oxygen; hemoglobin; oxygen affinity ... See more keywords
Haemoglobin Oxygen Affinity in Patients with Severe COVID‐19 Infection
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DOI: 10.1111/bjh.16888
Abstract: Abstract During critical care, at least until the late stage of the disease, severely ill COVID‐19 patients may have relatively well preserved lung compliance but remain severely hypoxaemic. A recent theoretical study suggested a direct… read more here.
Keywords: oxygen; patients severe; haemoglobin oxygen; affinity ... See more keywords
Influence of High Hemoglobin-Oxygen Affinity on Humans During Hypoxia
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Physiology"
DOI: 10.3389/fphys.2021.763933
Abstract: Humans elicit a robust series of physiological responses to maintain adequate oxygen delivery during hypoxia, including a transient reduction in hemoglobin-oxygen (Hb-O2) affinity. However, high Hb-O2 affinity has been identified as a beneficial adaptation in… read more here.
Keywords: affinity humans; affinity; oxygen affinity; hemoglobin oxygen ... See more keywords