Cooperation of HIF‐ and NCAM‐mediated mechanisms in cell viability of hippocampal cultures after oxygen–glucose deprivation
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DOI: 10.1002/cbin.10825
Abstract: Neurodegenerative diseases of different genesis are the result of cellular damages including those caused by oxygen and glucose deficit. Neuronal survival or death in brain pathologies depends on a variety of interrelated molecular mechanisms. A… read more here.
Keywords: cell viability; viability; glucose deprivation; oxygen glucose ... See more keywords
Glycine receptors are involved in hippocampal neuronal damage caused by oxygen‐glucose deficiency
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DOI: 10.1002/cbin.11034
Abstract: Glycine receptors (GlyRs) belong to the family of ligand‐gated cys‐loop receptors and effectuate fast inhibitory neurotransmission in central nervous system (CNS). They are involved in numerous physiological processes, such as movement, respiration, and processing of… read more here.
Keywords: neuronal damage; glycine receptors; glucose deficiency; oxygen glucose ... See more keywords
Asiaticoside attenuates oxygen–glucose deprivation/reoxygenation‐caused injury of cardiomyocytes by inhibiting autophagy
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Applied Toxicology"
DOI: 10.1002/jat.4424
Abstract: Asiaticoside is a natural triterpene compound derived from Centella asiatica, possessing confirmed cardioprotective property. However, the roles of asiaticoside in regulating oxygen–glucose deprivation/reoxygenation (OGD/R)‐caused cardiomyocyte dysfunction remain largely obscure. Human cardiomyocyte AC16 cells were stimulated… read more here.
Keywords: deprivation reoxygenation; cytotoxicity; glucose deprivation; oxygen glucose ... See more keywords
microRNA‐186 alleviates oxygen‐glucose deprivation/reoxygenation‐induced injury by directly targeting hypoxia‐inducible factor‐1α
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Biochemical and Molecular Toxicology"
DOI: 10.1002/jbt.22752
Abstract: Previous studies have suggested that microRNA‐186 (miR‐186) can be induced under hypoxic conditions, and is associated with apoptosis. This study was undertaken to explore the exact role of this microRNA (miRNA) in the apoptotic death… read more here.
Keywords: microrna 186; glucose deprivation; oxygen glucose; mir 186 ... See more keywords
Higenamine protects neuronal cells from oxygen‐glucose deprivation/reoxygenation‐induced injury
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DOI: 10.1002/jcb.27656
Abstract: Higenamine, a plant‐based alkaloid, exhibits various properties, such as antiapoptotic and antioxidative effects. Previous studies proved that higenamine possesses potential therapeutic effects for ischemia/reperfusion (I/R) injuries. However, the role of higenamine in cerebral I/R injury… read more here.
Keywords: neuronal cells; higenamine; glucose deprivation; higenamine protects ... See more keywords
LncRNA MALAT1 Promotes Oxygen-Glucose Deprivation and Reoxygenation Induced Cardiomyocytes Injury Through Sponging miR-20b to Enhance beclin1-Mediated Autophagy
Sign Up to like & getrecommendations! Published in 2019 at "Cardiovascular Drugs and Therapy"
DOI: 10.1007/s10557-019-06902-z
Abstract: LncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) is reported to be highly expressed in myocardial I/R injury and closely related to autophagy. However, the exact biological role of MALAT1 and its underlying mechanism in myocardial… read more here.
Keywords: beclin1; glucose deprivation; malat1; oxygen glucose ... See more keywords
Neuroprotective Effect of Oxysophocarpine by Modulation of MAPK Pathway in Rat Hippocampal Neurons Subject to Oxygen–Glucose Deprivation and Reperfusion
Sign Up to like & getrecommendations! Published in 2017 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-017-0501-5
Abstract: Oxysophocarpine (OSC), an alkaloid isolated from Sophora flavescens Ait, has been traditionally used as a medicinal agent based on the observed pharmacological effects. In this study, the direct effect of OSC against neuronal injuries induced… read more here.
Keywords: hippocampal neurons; glucose deprivation; oxysophocarpine; effect ... See more keywords
Minocycline Promotes BDNF Expression of N2a Cells via Inhibition of miR-155-Mediated Repression After Oxygen-Glucose Deprivation and Reoxygenation
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DOI: 10.1007/s10571-018-0599-0
Abstract: Minocycline, an anti-infective agent of a tetracycline derivative, is reported to improve behavioral functional recovery after cerebral ischemia via enhancing the levels of brain-derived neurotrophic factor (BDNF). However, the precise mechanisms that minocycline targets to… read more here.
Keywords: minocycline; mir 155; expression; oxygen glucose ... See more keywords
The p38/CYLD Pathway is Involved in Necroptosis Induced by Oxygen-glucose Deprivation Combined with ZVAD in Primary Cortical Neurons
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DOI: 10.1007/s11064-017-2244-6
Abstract: Recently, necroptosis, a form of programmed necrosis, has been widely studied. It has previously been shown that knockout of lysine 63 deubiquitinase CYLD significantly inhibits necroptosis in other cell lines, and serum response factor (SRF)… read more here.
Keywords: ogd zvad; necroptosis induced; glucose deprivation; necroptosis ... See more keywords
Knockdown of TRIM32 Protects Hippocampal Neurons from Oxygen–Glucose Deprivation-Induced Injury
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DOI: 10.1007/s11064-019-02857-7
Abstract: Tripartite motif 32 (TRIM32) is a member of TRIM family that plays a potential role in neural regeneration. However, the biological function of TRIM32 in cerebral ischemia reperfusion injury has not been investigated. In the… read more here.
Keywords: hippocampal neurons; knockdown trim32; glucose deprivation; oxygen glucose ... See more keywords
PKCγ and PKCε are Differentially Activated and Modulate Neurotoxic Signaling Pathways During Oxygen Glucose Deprivation in Rat Cortical Slices
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DOI: 10.1007/s11064-019-02876-4
Abstract: Cerebral ischemia is known to trigger a series of intracellular events such as changes in metabolism, membrane function and intracellular transduction, which eventually leads to cell death. Many of these processes are mediated by intracellular… read more here.
Keywords: glucose deprivation; cortical slices; oxygen glucose; pkc ... See more keywords