The Sanger Mouse Genetics Project: Understanding Neonatal Lethality
Sign Up to like & getrecommendations! Published in 2017 at "Mechanisms of Development"
DOI: 10.1016/j.mod.2017.04.359
Abstract: multiple oxygen-independent factors promoting HIF-1α stabilization. In cancer, the Warburg effect/pseudohypoxia, a state characterized for a change from aerobic to anaerobic metabolism, can promote HIF-1α stabilization through PHDs inhibition by 2oxoglutarate reduction. In neural crest… read more here.
Keywords: stabilization; genetics; hif stabilization; pdgf1a ... See more keywords
Pdgf1aa regulates zebrafish neural crest cells migration through Hif-1 in an oxygen-independent manner
Sign Up to like & getrecommendations! Published in 2018 at "Mechanisms of development"
DOI: 10.1016/j.mod.2018.07.007
Abstract: The transcription factor Hif-1α regulates epithelial to mesenchymal transition and neural crest cell chemotaxis in Xenopus. Hif-1α is only stabilised under low oxygen levels, and the in vivo stabilisation of this factor in neural crest… read more here.
Keywords: crest cells; hif; oxygen independent; neural crest ... See more keywords
Spatial and Temporal Resolution of the Oxygen-Independent Photoinduced DNA Interstrand Cross-Linking by a Nitroimidazole Derivative
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.2c00460
Abstract: DNA damage is ubiquitous in nature and is at the basis of emergent treatments such as photodynamic therapy, which is based on the activation of highly oxidative reactive oxygen species by photosensitizing O2. However, hypoxia… read more here.
Keywords: dna; oxygen independent; dna damage; dna interstrand ... See more keywords
A metal-semiconductor nanocomposite as an efficient oxygen-independent photosensitizer for photodynamic tumor therapy.
Sign Up to like & getrecommendations! Published in 2017 at "Nanoscale horizons"
DOI: 10.1039/c7nh00087a
Abstract: Photodynamic therapy (PDT) is regarded as one of the most promising cancer treatments, and oxygen-independent photosensitizers have been intensively explored for advancing the development of PDT. Here, we reported on a superior hybrid nanocomposite (HNC)… read more here.
Keywords: oxygen; oxygen independent; tumor therapy; independent photosensitizer ... See more keywords
Identification of Oxygen-Independent Pathways for Pyridine Nucleotide and Coenzyme A Synthesis in Anaerobic Fungi by Expression of Candidate Genes in Yeast
Sign Up to like & getrecommendations! Published in 2021 at "mBio"
DOI: 10.1128/mbio.00967-21
Abstract: NAD (NAD+) and coenzyme A (CoA) are central metabolic cofactors whose canonical biosynthesis pathways in fungi require oxygen. Anaerobic gut fungi of the Neocallimastigomycota phylum are unique eukaryotic organisms that adapted to anoxic environments. ABSTRACT… read more here.
Keywords: coenzyme synthesis; pyridine nucleotide; anaerobic fungi; oxygen ... See more keywords