Secretogranin III stringently regulates pathological but not physiological angiogenesis in oxygen-induced retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Cellular and Molecular Life Sciences"
DOI: 10.1007/s00018-021-04111-2
Abstract: Conventional angiogenic factors, such as vascular endothelial growth factor (VEGF), regulate both pathological and physiological angiogenesis indiscriminately, and their inhibitors may elicit adverse side effects. Secretogranin III (Scg3) was recently reported to be a diabetes-restricted… read more here.
Keywords: pathological physiological; angiogenesis; scg3; secretogranin iii ... See more keywords
Anti-angiogenic effect of Interleukin-26 in oxygen-induced retinopathy mice via inhibiting NFATc1-VEGF pathway.
Sign Up to like & getrecommendations! Published in 2018 at "Biochemical and biophysical research communications"
DOI: 10.1016/j.bbrc.2018.04.004
Abstract: Retinal neovascularization (RNV) is a devastating pathological feature of numerous ocular diseases and is a major cause of blindness. In this study, we examined the effect and potential mechanism of interleukin-26 (IL-26) in the pathogenesis… read more here.
Keywords: oxygen induced; oxygen; rnv; induced retinopathy ... See more keywords
A machine learning approach for automated assessment of retinal vasculature in the oxygen induced retinopathy model
Sign Up to like & getrecommendations! Published in 2018 at "Scientific Reports"
DOI: 10.1038/s41598-018-22251-7
Abstract: Preclinical studies of vascular retinal diseases rely on the assessment of developmental dystrophies in the oxygen induced retinopathy rodent model. The quantification of vessel tufts and avascular regions is typically computed manually from flat mounted… read more here.
Keywords: oxygen induced; machine; machine learning; learning approach ... See more keywords
Celastrol inhibits pathologic neovascularization in oxygen-induced retinopathy by targeting the miR-17-5p/HIF-1α/VEGF pathway
Sign Up to like & getrecommendations! Published in 2022 at "Cell Cycle"
DOI: 10.1080/15384101.2022.2087277
Abstract: ABSTRACT Retinopathy of prematurity (ROP), which is characterized by retinal neovascularization (RNV), is a major cause of neonatal blindness. The primary treatment for ROP is anti-vascular endothelial growth factor (VEGF) therapy, which is costly and… read more here.
Keywords: cell; oxygen induced; induced retinopathy; hif ... See more keywords
Long non-coding RNA MALAT1 participates in the pathological angiogenesis of diabetic retinopathy in oxygen-induced retinopathy mouse model by sponging miR-203a-3p.
Sign Up to like & getrecommendations! Published in 2019 at "Canadian journal of physiology and pharmacology"
DOI: 10.1139/cjpp-2019-0489
Abstract: Diabetic retinopathy (DR) is a devastating complication of diabetes. The aim of the present study is to investigate the exact role and mechanism of lncRNA MALAT1 (MALAT1) in the progress of DR. Oxygen-induced retinopathy (OIR)… read more here.
Keywords: oxygen induced; mir 203a; diabetic retinopathy; induced retinopathy ... See more keywords
MicroRNA Expression Analysis of Mice Retinas with Oxygen-Induced Retinopathy by RNA Sequencing
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Ophthalmology"
DOI: 10.1155/2022/9738068
Abstract: Purpose To characterize the microRNA (miRNA) expression profiles in the retinas of mice with oxygen-induced retinopathy by RNA sequencing and to ascertain miRNAs associated with retinal neovascularization. Methods Retina samples were obtained from 3 groups… read more here.
Keywords: expression; rna sequencing; mice; oxygen induced ... See more keywords
Hyaloid Vasculature as a Major Source of STAT3+ (Signal Transducer and Activator of Transcription 3) Myeloid Cells for Pathogenic Retinal Neovascularization in Oxygen-Induced Retinopathy
Sign Up to like & getrecommendations! Published in 2020 at "Arteriosclerosis, Thrombosis, and Vascular Biology"
DOI: 10.1161/atvbaha.120.314567
Abstract: Supplemental Digital Content is available in the text. Objective: Myeloid cells are critically involved in inflammation-induced angiogenesis, although their pathogenic role in the ischemic retina remains controversial. We hypothesize that myeloid cells contribute to pathogenic… read more here.
Keywords: hyaloid vasculature; neovascularization; induced retinopathy; myeloid cells ... See more keywords
Identification of reference genes for the normalization of retinal mRNA expression by RT-qPCR in oxygen induced retinopathy, anemia, and erythropoietin administration
Sign Up to like & getrecommendations! Published in 2023 at "PLOS ONE"
DOI: 10.1371/journal.pone.0284764
Abstract: Background Anemia and retinopathy of prematurity (ROP) are common comorbidities experienced by preterm infants, yet the role of anemia on the pathogenesis of ROP remains unclear. Reverse-transcriptase quantitative polymerase chain reaction (RT-qPCR) is a sensitive… read more here.
Keywords: reference; oxygen induced; induced retinopathy; anemia erythropoietin ... See more keywords
VEGF-Trap Modulates Retinal Inflammation in the Murine Oxygen-Induced Retinopathy (OIR) Model
Sign Up to like & getrecommendations! Published in 2022 at "Biomedicines"
DOI: 10.3390/biomedicines10020201
Abstract: Anti-Vascular Endothelial Growth Factor (VEGF) agents are the first-line treatment for retinal neovascular diseases, which represent the most prevalent causes of acquired vision loss world-wide. VEGF-Trap (Aflibercept, AFL), a recombinant decoy receptor recognizing ligands of… read more here.
Keywords: inflammation; oxygen induced; induced retinopathy; retinopathy oir ... See more keywords
Distinguished Functions of Microglia in the Two Stages of Oxygen-Induced Retinopathy: A Novel Target in the Treatment of Ischemic Retinopathy
Sign Up to like & getrecommendations! Published in 2022 at "Life"
DOI: 10.3390/life12101676
Abstract: Microglia is the resident immune cell in the retina, playing the role of immune surveillance in a traditional concept. With the heated focus on the mechanisms of microglia in pathological conditions, more and more functions… read more here.
Keywords: ischemic retinopathy; functions microglia; oxygen induced; induced retinopathy ... See more keywords
Identification of different macrophage subpopulations with distinct activities in a mouse model of oxygen-induced retinopathy
Sign Up to like & getrecommendations! Published in 2017 at "International Journal of Molecular Medicine"
DOI: 10.3892/ijmm.2017.3022
Abstract: The aim of the present study was to characterize the phenotypic shift, quantity and role changes in different subgroups of retinal macrophages in a mouse model of oxygen-induced retinopathy (OIR). The mRNA expression levels of… read more here.
Keywords: oxygen induced; induced retinopathy; model; model oxygen ... See more keywords