Discovery of SI 1/20 and SI 1/22 as Mutual Prodrugs of 5‐Fluorouracil and Imidazole‐Based Heme Oxygenase 1 Inhibitor with Improved Cytotoxicity in DU145 Prostate Cancer Cells
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DOI: 10.1002/cmdc.202300047
Abstract: In this work, we extend the concept of 5‐fluorouracil/heme oxygenase 1 (5‐FU/HO‐1) inhibitor hybrid as an effective strategy for enhancing 5‐FU‐based anticancer therapies. For this purpose, we designed and synthesized new mutual prodrugs, named SI… read more here.
Keywords: imidazole based; oxygenase inhibitor; mutual prodrugs; heme oxygenase ... See more keywords
Heme oxygenase‐1 inhibitor tin‐protoporphyrin improves liver regeneration after partial hepatectomy
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DOI: 10.1016/j.lfs.2018.05.011
Abstract: Aims: This study investigates the effects of the heme oxygenase‐1 (HO‐1) inhibitor tin protoporphyrin IX (SnPP), on rat liver regeneration following 2/3 partial hepatectomy (PH) in order to clarify the controversial role of HO‐1 in… read more here.
Keywords: oxygenase inhibitor; liver regeneration; regeneration; tin protoporphyrin ... See more keywords