The clinical and biochemical significance of 11-oxygenated androgens in human health and disease.
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DOI: 10.1093/ejendo/lvad047
Abstract: For many decades, the prevailing paradigm in endocrinology was that testosterone and 5α-dihydrotestosterone (DHT) are the only potent androgens in the context of human physiology. The more recent identification of adrenal derived 11-oxygenated androgens and… read more here.
Keywords: oxygenated androgens; endocrinology; human health; androgens human ... See more keywords
11-Oxygenated Estrogens Are a Novel Class of Human Estrogens but Do not Contribute to the Circulating Estrogen Pool.
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DOI: 10.1210/endocr/bqaa231
Abstract: Androgens are the obligatory precursors of estrogens. In humans, classic androgen biosynthesis yields testosterone, thought to represent the predominant circulating active androgen both in men and women. However, recent work has shown that 11-ketotestosterone, derived… read more here.
Keywords: androgen; pool; estrogen; oxygenated androgens ... See more keywords
Conversion of Classical and 11-oxygenated Androgens by Insulin Induced AKR1C3 in a Model of Human PCOS Adipocytes.
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DOI: 10.1210/endocr/bqac068
Abstract: Polycystic ovary syndrome (PCOS) is the most prevalent endocrinopathy in women. A common symptom of PCOS is hyperandrogenism (AE); however, the source of these androgens is uncertain. Aldo-keto reductase family 1 member C3 (AKR1C3) catalyzes… read more here.
Keywords: oxygenated androgens; conversion classical; pcos; classical oxygenated ... See more keywords
MON-203 Local Activation of 11-Oxygenated Androgens by AKR1C3 Is the Predominant Source of Androgens in Human Female Adipose Tissue
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DOI: 10.1210/js.2019-mon-203
Abstract: Abstract Polycystic ovary syndrome (PCOS) affects 10% of women and is a lifelong metabolic disorder, with increased risk of type 2 diabetes, fatty liver and cardiovascular disease. Androgen excess is an important driver of metabolic… read more here.
Keywords: adipose tissue; local activation; tissue; oxygenated androgens ... See more keywords
11-Oxygenated androgens are not secreted by the human ovary: in-vivo data from four different cases of hyperandrogenism
Sign Up to like & getrecommendations! Published in 2022 at "European Journal of Endocrinology"
DOI: 10.1530/eje-22-0518
Abstract: Objective Differentiation of an adrenal from an ovarian source of hyperandrogenemia can be challenging. Recent studies have highlighted the importance of 11-oxygenated C19 steroids to the androgen pool in humans. The aim of this study… read more here.
Keywords: oxygenated androgens; different cases; four different; human ovary ... See more keywords