Molecular Docking, Molecular Dynamics, and Structure–Activity Relationship Explorations of 14-Oxygenated N-Methylmorphinan-6-ones as Potent μ-Opioid Receptor Agonists
Sign Up to like & getrecommendations! Published in 2017 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.6b00460
Abstract: Among opioids, morphinans are of major importance as the most effective analgesic drugs acting primarily via μ-opioid receptor (μ-OR) activation. Our long-standing efforts in the field of opioid analgesics from the class of morphinans led… read more here.
Keywords: methylmorphinan ones; opioid receptor; activity relationship; structure activity ... See more keywords
Recent Chemical and Pharmacological Developments on 14-Oxygenated-N-methylmorphinan-6-ones
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DOI: 10.3390/molecules26185677
Abstract: Adequate pain management, particularly chronic pain, remains a major challenge associated with modern-day medicine. Current pharmacotherapy offers unsatisfactory long-term solutions due to serious side effects related to the chronic administration of analgesic drugs. Morphine and… read more here.
Keywords: methylmorphinan ones; chemical pharmacological; pharmacological developments; recent chemical ... See more keywords