Association of cerebrovascular dysfunction with the development of Alzheimer’s disease-like pathology in OXYS rats
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DOI: 10.1186/s12864-018-4480-9
Abstract: BackgroundCerebrovascular dysfunction plays a critical role in the pathogenesis of Alzheimer’s disease (AD): the most common cause of dementia in the elderly. The involvement of neurovasculature disorders in the progression of AD is now increasingly… read more here.
Keywords: like pathology; disease; pathology; oxys rats ... See more keywords
Immunohistochemical localization of NGF, BDNF, and their receptors in a normal and AMD-like rat retina
Sign Up to like & getrecommendations! Published in 2019 at "BMC Medical Genomics"
DOI: 10.1186/s12920-019-0493-8
Abstract: BackgroundAge-related macular degeneration (AMD) is a major cause of blindness in developed countries, and the molecular pathogenesis of AMD is poorly understood. A large body of evidence has corroborated the key role of neurotrophins in… read more here.
Keywords: amd like; ngf bdnf; oxys rats; localization ... See more keywords
Delayed Formation of Neonatal Reflexes and of Locomotor Skills Is Associated with Poor Maternal Behavior in OXYS Rats Prone to Alzheimer’s Disease-like Pathology
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DOI: 10.3390/biomedicines10112910
Abstract: Postnatal brain development is characterized by high plasticity with critical windows of opportunity where any intervention may positively or adversely influence postnatal growth and lead to long-lasting consequences later in life. Poor maternal care is… read more here.
Keywords: maternal behavior; alzheimer disease; pathology; disease like ... See more keywords
The Rat Brain Transcriptome: From Infancy to Aging and Sporadic Alzheimer’s Disease-like Pathology
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms24021462
Abstract: It has been suggested that functional traits of the adult brain—all of which are established early in life—may affect the brain’s susceptibility to Alzheimer’s disease (AD). Results of our previous studies on senescence-accelerated OXYS rats,… read more here.
Keywords: alzheimer disease; brain; pathology; oxys rats ... See more keywords