Structure-Activity Relationships of Ligand Binding to Oxysterol-Binding Protein (OSBP) and OSBP-Related Protein 4.
Sign Up to like & getrecommendations! Published in 2023 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01025
Abstract: Oxysterol-binding protein (OSBP) and OSBP-related protein 4 (ORP4) have emerged as potentially druggable targets in antiviral and precision cancer drug development. Multiple structurally diverse small molecules function through targeting the OSBP/ORP family of proteins, including… read more here.
Keywords: oxysterol binding; binding protein; osbp orp4; protein osbp ... See more keywords
Oxysterol-binding protein-related protein 1 variants have opposing cholesterol transport activities from the endolysosomes
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Biology of the Cell"
DOI: 10.1091/mbc.e19-12-0697
Abstract: OSBPL1 encodes the full-length oxysterol-binding protein-related protein ORP1L, which transports LDL-derived cholesterol at membrane contacts between the late endosomes/lysosomes (LEL) and the endoplasmic reticulum (ER). OSBPL1 also encodes the truncated variant ORP1S that contains only… read more here.
Keywords: protein related; oxysterol binding; orp1 null; cholesterol ... See more keywords
Inactivation of BoORP3a, an oxysterol-binding protein, causes a low wax phenotype in ornamental kale
Sign Up to like & getrecommendations! Published in 2022 at "Horticulture Research"
DOI: 10.1093/hr/uhac219
Abstract: Abstract Identifying genes associated with wax deposition may contribute to the genetic improvement of ornamental kale. Here, we characterized a candidate gene for wax contents, BoORP3a, encoding an oxysterol-binding protein. We sequenced the BoORP3a gene… read more here.
Keywords: oxysterol binding; binding protein; ornamental kale; low wax ... See more keywords
Fungal oxysterol-binding protein-related proteins promote pathogen virulence and activate plant immunity.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of experimental botany"
DOI: 10.1093/jxb/erab530
Abstract: Oxysterol-binding protein-related proteins (ORPs) are a conserved class of lipid transfer proteins that are closely involved in multiple cellular processes in eukaryotes but their roles in plant-pathogen interactions are mostly unknown. We showed that transient… read more here.
Keywords: protein related; virulence; binding protein; oxysterol binding ... See more keywords
Oxysterol-binding protein-like 3 is a novel target gene of peroxisome proliferator-activated receptor γ in fatty liver disease
Sign Up to like & getrecommendations! Published in 2023 at "Molecular and Cellular Endocrinology"
DOI: 10.2139/ssrn.4264340
Abstract: Oxysterol-binding protein-like 3 (OSBPL3) plays a key role in the development of fatty liver disease. Herein, we found that OSBPL3 is highly expressed in the fatty liver of humans and mice. Although high expression of… read more here.
Keywords: oxysterol binding; binding protein; liver; fatty liver ... See more keywords
Functions of Oxysterol-Binding Proteins at Membrane Contact Sites and Their Control by Phosphoinositide Metabolism
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.664788
Abstract: Lipids must be correctly transported within the cell to the right place at the right time in order to be fully functional. Non-vesicular lipid transport is mediated by so-called lipid transfer proteins (LTPs), which contain… read more here.
Keywords: membrane contact; metabolism; contact sites; oxysterol binding ... See more keywords
Oxysterol-Binding Protein 2 Promotes Pancreatic Ductal Adenocarcinoma Progression Through Epithelial-Mesenchymal Transition
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.762233
Abstract: Oxysterol-binding protein 2 (OSBP2) is crucial for promoting the growth and development of cancers; however, its effects on pancreatic ductal adenocarcinoma (PDAC) are still unclear. Here, we report that OSBP2 is an efficient tumor-associated protein… read more here.
Keywords: pancreatic ductal; binding protein; oxysterol binding; osbp2 ... See more keywords
Essential Domains of Oxysterol-Binding Protein Required for Poliovirus Replication
Sign Up to like & getrecommendations! Published in 2022 at "Viruses"
DOI: 10.3390/v14122672
Abstract: Oxysterol-binding protein (OSBP) is a host factor required for enterovirus (EV) replication. OSBP locates at membrane contact site and acts as a lipid exchanger of cholesterol and phosphatidylinositol 4-phosphate (PI4P) between cellular organelles; however, the… read more here.
Keywords: oxysterol binding; binding protein; essential domains; replication ... See more keywords