Oxysterol misbalance critically contributes to Wilson disease pathogenesis
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DOI: 10.1126/sciadv.adc9022
Abstract: Wilson disease (WD) is a metabolic disorder caused by inactivation of the copper-transporting ATPase 2 (ATP7B) and copper (Cu) overload in tissues. Excess Cu causes oxidative stress and pathologic changes with poorly understood mechanistic connections.… read more here.
Keywords: oxysterol misbalance; wilson disease; misbalance critically; critically contributes ... See more keywords