The Multidimensional Therapeutic Potential of Targeting the Brain Oxytocin System for the Treatment of Substance Use Disorders.
Sign Up to like & getrecommendations! Published in 2018 at "Current topics in behavioral neurosciences"
DOI: 10.1007/7854_2017_17
Abstract: The neuropeptide oxytocin is released both into the blood and within the brain in response to reproductive stimuli, such as birth, suckling and sex, but also in response to social interaction and stressors. Substance use… read more here.
Keywords: brain; oxytocin system; use disorders; substance use ... See more keywords
Oxytocin system dysfunction in patients with treatment-resistant schizophrenia: Alterations of blood oxytocin levels and effect of a genetic variant of OXTR.
Sign Up to like & getrecommendations! Published in 2021 at "Journal of psychiatric research"
DOI: 10.1016/j.jpsychires.2021.03.053
Abstract: Treatment-resistant schizophrenia (TRS) has a quite complex pathophysiology that includes not only severe positive symptoms but also other symptom domains. Much attention has been devoted to the overlapping psychological and biological profiles of schizophrenia and… read more here.
Keywords: resistant schizophrenia; treatment resistant; system dysfunction; oxytocin system ... See more keywords
Targeting the Oxytocin System: New Pharmacotherapeutic Approaches.
Sign Up to like & getrecommendations! Published in 2019 at "Trends in pharmacological sciences"
DOI: 10.1016/j.tips.2018.11.001
Abstract: Deficits in social behavioral domains, such as interpersonal communication, emotion recognition, and empathy, are a characteristic symptom in several neuropsychiatric disorders, including schizophrenia and autism spectrum disorder (ASD). The neuropeptide oxytocin (OT) has emerged as… read more here.
Keywords: pharmacotherapeutic approaches; targeting oxytocin; oxytocin system; new pharmacotherapeutic ... See more keywords
Tryptophan Hydroxylase 2 Knockout Male Rats Exhibit a Strengthened Oxytocin System, Are Aggressive, and Are Less Anxious
Sign Up to like & getrecommendations! Published in 2022 at "ACS Chemical Neuroscience"
DOI: 10.1021/acschemneuro.2c00448
Abstract: The central serotoninergic system is critical for stress responsivity and social behavior, and its dysregulations have been centrally implicated in virtually all neuropsychiatric disorders. Genetic serotonin depletion animal models could provide a tool to elucidate… read more here.
Keywords: system; male rats; tryptophan hydroxylase; oxytocin system ... See more keywords
Editorial: The Oxytocin System in Fear, Stress, Anguish, and Pain
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Endocrinology"
DOI: 10.3389/fendo.2021.737953
Abstract: 1 Department of Pharmacology & Toxicology, University of Kansas, Lawrence, KS, United States, 2 Institute of Molecular and Cellular Anatomy, University of Regensburg, Regensburg, Germany, 3 Department of Neuropeptide Research in Psychiatry, Central Institute of… read more here.
Keywords: editorial oxytocin; oxytocin system; sydney; fear stress ... See more keywords
Barriers and Breakthroughs in Targeting the Oxytocin System to Treat Alcohol Use Disorder
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Psychiatry"
DOI: 10.3389/fpsyt.2022.842609
Abstract: Development of better treatments for alcohol use disorder (AUD) is urgently needed. One promising opportunity for this development is the potential of targeting the oxytocin peptide system. Preclinical studies showed that administration of exogenous oxytocin… read more here.
Keywords: system; targeting oxytocin; alcohol use; use disorder ... See more keywords