Haloperidol Prevents Oxytosis/Ferroptosis by Targeting Lysosomal Ferrous Ions in a Manner Independent of Dopamine D2 and Sigma-1 Receptors.
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DOI: 10.1021/acschemneuro.2c00398
Abstract: Haloperidol is a widely used antipsychotic agent that exerts antipsychotic effects through a strong antagonism of dopamine D2 receptors. In addition, haloperidol is classified as a sigma-1 receptor (S1R) antagonist that prevents endogenous oxidative stress… read more here.
Keywords: lysosomal ferrous; ferrous ions; oxytosis ferroptosis; dopamine ... See more keywords