A Chemoselective α-Oxytriflation Enables the Direct Asymmetric Arylation of Amides
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DOI: 10.1016/j.chempr.2019.05.006
Abstract: Summary Until recently, the direct oxidative oxysulfonylation of carbonyl compounds was limited to ketones. Here, we report the first direct oxytriflation of simple, non-activated amides. Amide umpolung with triflic anhydride and pyridine-N-oxide in the absence… read more here.
Keywords: asymmetric arylation; enables direct; arylation; oxytriflation enables ... See more keywords