Ozonide antimalarials alkylate heme in the malaria parasite Plasmodium falciparum.
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DOI: 10.1021/acsinfecdis.9b00257
Abstract: The mechanism of action of ozonide antimalarials involves activation by intraparasitic iron and the formation of highly reactive carbon-centred radicals that alkylate malaria parasite proteins. Given free intraparasitic heme is generally thought to be the… read more here.
Keywords: malaria parasite; heme; parasite plasmodium; ozonide antimalarials ... See more keywords