Remineralization effects of self-assembling peptide P11 -4 associated with three materials on early enamel carious lesions: An in vitro study.
Sign Up to like & getrecommendations! Published in 2021 at "Microscopy research and technique"
DOI: 10.1002/jemt.23937
Abstract: The aim of this study was to assess the remineralization of enamel caries lesions using the self-assembling peptide P11 -4 associated with different materials. Artificial early enamel lesions were prepared on 154 primary teeth. The… read more here.
Keywords: p11; self assembling; microscopy; peptide p11 ... See more keywords
Randomised clinical trial investigating self-assembling peptide P11-4 in the treatment of early caries
Sign Up to like & getrecommendations! Published in 2019 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-019-02901-4
Abstract: ObjectivesThis prospective, randomised, split-mouth, clinical trial compared the efficacy of the self-assembling peptide P11-4 to fluoride varnish in the treatment of early buccal carious lesions.Materials and methodsSubjects presenting at least two clinically affected teeth were… read more here.
Keywords: p11; self assembling; peptide p11; treatment ... See more keywords
The effect of nano silver fluoride, self-assembling peptide and sodium fluoride varnish on salivary cariogenic bacteria: a randomized controlled clinical trial
Sign Up to like & getrecommendations! Published in 2024 at "Clinical Oral Investigations"
DOI: 10.1007/s00784-024-05562-0
Abstract: To compare the antibacterial effect of Nanosilver Fluoride varnish (NSF) varnish, P11-4 and Sodium Fluoride (NaF) varnish against salivary Streptococcus mutans (S. mutans) and Lactobacilli. 66 patients aged 10–24 years old were randomly assigned to… read more here.
Keywords: month; effect; p11; sodium fluoride ... See more keywords
Neu‐P11, a novel MT1/MT2 agonist, reverses diabetes by suppressing the hypothalamic‐pituitary‐adrenal axis in rats
Sign Up to like & getrecommendations! Published in 2017 at "European Journal of Pharmacology"
DOI: 10.1016/j.ejphar.2017.07.001
Abstract: &NA; Excessive glucocorticoid (GC) in type 2 diabetes mellitus (T2DM) reduces insulin sensitivity, impairs &bgr;‐cell function, increases gluconeogenesis and glycogenolysis, impairs glucose uptake and metabolism, and reduces the insulinotropic effects of glucagon‐like peptide 1. Melatonin,… read more here.
Keywords: mt1 mt2; neu p11; p11; axis ... See more keywords
Discovery of P11-2: A Potent First-in-Class MNK1-Targeting PROTAC Degrader for the Treatment of Cancer.
Sign Up to like & getrecommendations! Published in 2025 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.5c00062
Abstract: MAPK-interacting kinases (MNKs) are the only known kinases that phosphorylate eIF4E at Ser209, playing a critical role in tumor progression. However, the current MNK inhibitors have been limited due to the deficiency of effectiveness. Herein,… read more here.
Keywords: first class; p11; mnk1 targeting; mnk1 ... See more keywords
Early life stress induces age-dependent epigenetic changes in p11 gene expression in male mice
Sign Up to like & getrecommendations! Published in 2021 at "Scientific Reports"
DOI: 10.1038/s41598-021-89593-7
Abstract: Early life stress (ELS) causes long-lasting changes in gene expression through epigenetic mechanisms. However, little is known about the effects of ELS in adulthood, specifically across different age groups. In this study, the epigenetic modifications… read more here.
Keywords: methylation; p11; age; expression ... See more keywords