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Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105415
Abstract: Genetically modified animal studies have revealed specific expression patterns and unequivocal roles of class I PI3K isoenzymes. PI3K(p110α), a catalytic subunit of class I PI3Ks is ubiquitously expressed and is well characterised in the cardiovascular…
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Keywords:
atrial fibrillation;
pathophysiology;
p110;
pi3k p110 ... See more keywords
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Published in 2017 at "Scientific Reports"
DOI: 10.1038/s41598-017-16029-6
Abstract: Rab5 is a small monomeric GTPase that mediates protein trafficking during endocytosis. Inactivation of Rab5 by GTP hydrolysis causes a conformational change that masks binding sites on its “switch regions” from downstream effectors. The p85…
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Keywords:
rab5;
p110;
rab5 gtp;
phosphatidylinositol kinase ... See more keywords
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Published in 2017 at "Bioscience Reports"
DOI: 10.1042/bsr20160258
Abstract: In higher eukaryotes, cell proliferation is regulated by class I phosphatidylinositol 3-kinase (PI3K), which transduces stimuli received from neighboring receptors by local generation of PtdIns(3,4,5)P3 in cellular membranes. PI3K is a heterodimeric protein consisting of…
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Keywords:
p85 mutations;
p110;
phosphatidylinositol kinase;
model ... See more keywords
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Published in 2018 at "Neuro-Oncology"
DOI: 10.1093/neuonc/nox181
Abstract: Background Glioblastoma (GBM) is difficult to treat. Phosphoinositide 3-kinase (PI3K) is an attractive therapeutic target for GBM; however, targeting this pathway to effectively treat GBM is not successful because the roles of PI3K isoforms remain…
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Keywords:
pi3k isoforms;
gbm;
p110;
pik3cb p110 ... See more keywords
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Published in 2022 at "Science Advances"
DOI: 10.1126/sciadv.abq8109
Abstract: Neuronal connectivity and activity-dependent synaptic plasticity are fundamental properties that support brain function and cognitive performance. Phosphatidylinositol 3-kinase (PI3K) intracellular signaling controls multiple mechanisms mediating neuronal growth, synaptic structure, and plasticity. However, it is still…
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Keywords:
pi3k;
p110;
plasticity;
functional specialization ... See more keywords
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Published in 2018 at "Cancer Research"
DOI: 10.1158/1538-7445.am2018-4988
Abstract: Pancreatic ductal adenocarcinoma (PDAC) presents a significant challenge clinically, with poor overall survival and widespread resistance to conventional therapies. Several novel molecular targets are being considered in the management of PDAC patients. To this end,…
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Keywords:
pi3k;
p110;
tumorigenesis;
hepatotoxicity ... See more keywords
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Published in 2020 at "Molecular Cancer Research"
DOI: 10.1158/1557-3125.pi3k-mtor18-a15
Abstract: Background: The divergent roles of phosphatidylinositide 3-kinase (PI3K) family genes in cancer pathogenesis and progression have been highly studied. PI3K genes are divided into three classes (I, II, and III). Class IA PI3K includes three…
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Keywords:
p110;
pik3cb p110;
resistance;
pi3k ... See more keywords
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Published in 2018 at "Blood"
DOI: 10.1182/blood-2018-99-114891
Abstract: Hematopoietic stem cells (HSCs) are a rare population in the bone marrow (BM) that mostly exists in a quiescent state. Upon environmental stresses such as infection, inflammatory signals are released and induce HSCs to proliferate…
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Keywords:
dko;
p110;
il1 tnf;
p110 p110 ... See more keywords
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Published in 2020 at "Diabetes"
DOI: 10.2337/db19-0713
Abstract: Diabetic retinopathy is the most common microvascular complication of diabetes, and in the advanced diabetic retinopathy appear vitreal fibrovascular membranes that consist of a variety of cells, including vascular endothelial cells (ECs). New therapeutic approaches…
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Keywords:
p110;
diabetic retinopathy;
angiogenesis;
growth factor ... See more keywords
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Published in 2017 at "Haematologica"
DOI: 10.3324/haematol.2017.167601
Abstract: Class I phosphoinositide-3-kinases (PI3Ks) convert phosphoinositol-4,5-bisphosphate to phosphoinositol3,4,5-trisphosphate, a lipid second messenger produced mainly at plasma membranes where it recruits and activates pleckstrin homology domain-containing proteins, including the well known protein kinase AKT. Class IA…
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Keywords:
binding domain;
p110;
pi3k syndrome;
activated pi3k ... See more keywords
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Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2022.928210
Abstract: Pregnancy requires adaptations in maternal metabolism to support fetal growth. The phosphoinositol-3-kinase (PI3K) signalling pathway controls multiple biological processes and defects in this pathway are linked to metabolic disorders including insulin resistance and glucose intolerance…
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Keywords:
pi3k;
maternal metabolic;
metabolic adaptations;
p110 ... See more keywords