Pathophysiology and Therapeutic Relevance of PI3K(p110α) Protein in Atrial Fibrillation - A Non-interventional Molecular Therapy Strategy.
Sign Up to like & getrecommendations! Published in 2021 at "Pharmacological research"
DOI: 10.1016/j.phrs.2020.105415
Abstract: Genetically modified animal studies have revealed specific expression patterns and unequivocal roles of class I PI3K isoenzymes. PI3K(p110α), a catalytic subunit of class I PI3Ks is ubiquitously expressed and is well characterised in the cardiovascular… read more here.
Keywords: atrial fibrillation; pathophysiology; p110; pi3k p110 ... See more keywords
Identification of the Binding Sites on Rab5 and p110beta Phosphatidylinositol 3-kinase
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DOI: 10.1038/s41598-017-16029-6
Abstract: Rab5 is a small monomeric GTPase that mediates protein trafficking during endocytosis. Inactivation of Rab5 by GTP hydrolysis causes a conformational change that masks binding sites on its “switch regions” from downstream effectors. The p85… read more here.
Keywords: rab5; p110; rab5 gtp; phosphatidylinositol kinase ... See more keywords
Insights into the pathological mechanisms of p85α mutations using a yeast-based phosphatidylinositol 3-kinase model
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DOI: 10.1042/bsr20160258
Abstract: In higher eukaryotes, cell proliferation is regulated by class I phosphatidylinositol 3-kinase (PI3K), which transduces stimuli received from neighboring receptors by local generation of PtdIns(3,4,5)P3 in cellular membranes. PI3K is a heterodimeric protein consisting of… read more here.
Keywords: p85 mutations; p110; phosphatidylinositol kinase; model ... See more keywords
PIK3CB/p110&bgr; is a selective survival factor for glioblastoma
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DOI: 10.1093/neuonc/nox181
Abstract: Background Glioblastoma (GBM) is difficult to treat. Phosphoinositide 3-kinase (PI3K) is an attractive therapeutic target for GBM; however, targeting this pathway to effectively treat GBM is not successful because the roles of PI3K isoforms remain… read more here.
Keywords: pi3k isoforms; gbm; p110; pik3cb p110 ... See more keywords
Functional specialization of different PI3K isoforms for the control of neuronal architecture, synaptic plasticity, and cognition
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DOI: 10.1126/sciadv.abq8109
Abstract: Neuronal connectivity and activity-dependent synaptic plasticity are fundamental properties that support brain function and cognitive performance. Phosphatidylinositol 3-kinase (PI3K) intracellular signaling controls multiple mechanisms mediating neuronal growth, synaptic structure, and plasticity. However, it is still… read more here.
Keywords: pi3k; p110; plasticity; functional specialization ... See more keywords
Abstract 4988: PI3Kγ-deficiency protects against pancreatic tumorigenesis at the expense of diet-Induced hyperlipidemia and hepatotoxicity
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DOI: 10.1158/1538-7445.am2018-4988
Abstract: Pancreatic ductal adenocarcinoma (PDAC) presents a significant challenge clinically, with poor overall survival and widespread resistance to conventional therapies. Several novel molecular targets are being considered in the management of PDAC patients. To this end,… read more here.
Keywords: pi3k; p110; tumorigenesis; hepatotoxicity ... See more keywords
Abstract A15: The selective role of PIK3CB/p110β in temozolomide resistance in glioblastoma
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DOI: 10.1158/1557-3125.pi3k-mtor18-a15
Abstract: Background: The divergent roles of phosphatidylinositide 3-kinase (PI3K) family genes in cancer pathogenesis and progression have been highly studied. PI3K genes are divided into three classes (I, II, and III). Class IA PI3K includes three… read more here.
Keywords: p110; pik3cb p110; resistance; pi3k ... See more keywords
PI3Kinase Alpha and Delta Promote Hematopoietic Stem Activation Under Stress
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DOI: 10.1182/blood-2018-99-114891
Abstract: Hematopoietic stem cells (HSCs) are a rare population in the bone marrow (BM) that mostly exists in a quiescent state. Upon environmental stresses such as infection, inflammatory signals are released and induce HSCs to proliferate… read more here.
Keywords: dko; p110; il1 tnf; p110 p110 ... See more keywords
PI3Kδ as a Novel Therapeutic Target in Pathological Angiogenesis
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DOI: 10.2337/db19-0713
Abstract: Diabetic retinopathy is the most common microvascular complication of diabetes, and in the advanced diabetic retinopathy appear vitreal fibrovascular membranes that consist of a variety of cells, including vascular endothelial cells (ECs). New therapeutic approaches… read more here.
Keywords: p110; diabetic retinopathy; angiogenesis; growth factor ... See more keywords
Mutations in the adaptor-binding domain and associated linker region of p110δ cause Activated PI3K-δ Syndrome 1 (APDS1)
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DOI: 10.3324/haematol.2017.167601
Abstract: Class I phosphoinositide-3-kinases (PI3Ks) convert phosphoinositol-4,5-bisphosphate to phosphoinositol3,4,5-trisphosphate, a lipid second messenger produced mainly at plasma membranes where it recruits and activates pleckstrin homology domain-containing proteins, including the well known protein kinase AKT. Class IA… read more here.
Keywords: binding domain; p110; pi3k syndrome; activated pi3k ... See more keywords
Ablation of PI3K-p110alpha Impairs Maternal Metabolic Adaptations to Pregnancy
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DOI: 10.3389/fcell.2022.928210
Abstract: Pregnancy requires adaptations in maternal metabolism to support fetal growth. The phosphoinositol-3-kinase (PI3K) signalling pathway controls multiple biological processes and defects in this pathway are linked to metabolic disorders including insulin resistance and glucose intolerance… read more here.
Keywords: pi3k; maternal metabolic; metabolic adaptations; p110 ... See more keywords