Protective effect of lupeol on arthritis induced by type II collagen via the suppression of P13K/AKT signaling pathway in Sprague dawley rats.
Sign Up to like & getrecommendations! Published in 2022 at "Environmental toxicology"
DOI: 10.1002/tox.23529
Abstract: To explore the therapeutic value of lupeol on collagen-induced arthritis (CIA) in rats, a rheumatoid arthritis model. Lupeol is well known pentacyclic triterpene found in various plant sources, which possess anti-inflammatory and antioxidant actions. The… read more here.
Keywords: p13k akt; lupeol; arthritis; akt signaling ... See more keywords
Venlafaxine exerts antidepressant effects possibly by activating MAPK–ERK1/2 and P13K–AKT pathways in the hippocampus
Sign Up to like & getrecommendations! Published in 2017 at "Behavioural Brain Research"
DOI: 10.1016/j.bbr.2017.08.011
Abstract: Serotonin noradrenaline reuptake inhibitors are effective antidepressant drugs, which include venlafaxine and duloxetine. Venlafaxine is commonly used in a clinical context, but the molecular biological mechanisms behind its effects have not been fully determined. Here,… read more here.
Keywords: akt; mapk erk1; venlafaxine; erk1 p13k ... See more keywords
Selenium nanoparticles with various morphology for antiangiogenesis through bFGF-mediated P13K/AKT signaling pathways
Sign Up to like & getrecommendations! Published in 2021 at "Nanotechnology"
DOI: 10.1088/1361-6528/ac0d1d
Abstract: Selenium nanoparticles (Se NPs) have potential antitumor activity and immune properties. However, the mechanism between its antitumor activity and nanoparticle morphology has not been evaluated. Therefore, a simple method was used to synthesize three special… read more here.
Keywords: bfgf; nanoparticles nps; selenium nanoparticles; p13k akt ... See more keywords
Identification of novel inhibitors of P13K/AKT pathways: an integrated in-silico study towards the development of a new therapeutic agent against ovarian cancer
Sign Up to like & getrecommendations! Published in 2023 at "Physical Sciences Reviews"
DOI: 10.1515/psr-2022-0341
Abstract: Abstract Ovarian cancer is a crucial gynaecological unmet medical disease with a high mortality rate. According to recent research, the phosphoinositol 3 kinase (PI3K)/protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathways are hyper-activated in… read more here.
Keywords: inhibitors p13k; ovarian cancer; kcal mol; p13k akt ... See more keywords
MicroRNA-936 promotes proliferation and invasion of gastric cancer cells by down-regulating FGF2 expression and activating P13K/Akt signaling pathway.
Sign Up to like & getrecommendations! Published in 2020 at "European review for medical and pharmacological sciences"
DOI: 10.26355/eurrev_202006_21658
Abstract: OBJECTIVE This study was designed to investigate whether microRNA-936 can be involved in the development of gastric cancer (GCa) by down-regulating FGF2 expression and activating the phosphatidylinositol 3-kinase/protein kinase B (P13K/Akt) signaling pathway. PATIENTS AND… read more here.
Keywords: fgf2 expression; microrna 936; gca; expression ... See more keywords