CRL2-KLHDC3 E3 ubiquitin ligase complex suppresses ferroptosis through promoting p14ARF degradation.
Sign Up to like & getrecommendations! Published in 2021 at "Cell death and differentiation"
DOI: 10.1038/s41418-021-00890-0
Abstract: The cystine/glutamate antiporter SLC7A11 (commonly known as xCT) functions to import cystine for glutathione biosynthesis, thereby protecting cells from oxidative stress and ferroptosis, a regulated form of non-apoptotic cell death driven by the accumulation of… read more here.
Keywords: crl2 klhdc3; p14arf; ubiquitin ligase; klhdc3 ... See more keywords
Clinical significance of p16INK4A and p14ARF promoter methylation in renal cell carcinoma: a meta-analysis.
Sign Up to like & getrecommendations! Published in 2017 at "Oncotarget"
DOI: 10.18632/oncotarget.18826
Abstract: The inactivation of p16INK4A and p14ARF via promoter methylation has been investigated in various cancers. However, the clinical effects of p16INK4A and p14ARF promoter methylation on renal cell carcinoma (RCC) remain to be clarified. The… read more here.
Keywords: p14arf; methylation; promoter methylation; p16ink4a p14arf ... See more keywords