p150glued deficiency impairs effective fusion between autophagosomes and lysosomes due to their redistribution to the cell periphery
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DOI: 10.1016/j.neulet.2018.10.036
Abstract: Dynein-dynactin has an indispensable role in autophagy and p150glued is the largest component of the dynactin complex. Here, we characterized the effects of knockdown (KD) of endogenous p150glued and of the pathogenic mutation of p150glued… read more here.
Keywords: autophagosomes lysosomes; p150glued deficiency; periphery p150glued; fusion ... See more keywords