Pyrrolysine-Inspired in Cellulo Synthesis of an Unnatural Amino Acid for Facile Macrocyclization of Proteins
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DOI: 10.1021/jacs.3c01291
Abstract: Macrocyclization has been touted as an effective strategy to enhance the in vivo stability and efficacy of protein therapeutics. Herein, we describe a scalable and robust system based on the endogenous biosynthesis of a noncanonical… read more here.
Keywords: amino acid; protein; macrocyclization; amino ... See more keywords