Critical domain interactions for type A RNase P RNA catalysis with and without the specificity domain
Sign Up to like & getrecommendations! Published in 2018 at "PLoS ONE"
DOI: 10.1371/journal.pone.0192873
Abstract: The natural trans-acting ribozyme RNase P RNA (RPR) is composed of two domains in which the catalytic (C-) domain mediates cleavage of various substrates. The C-domain alone, after removal of the second specificity (S-) domain,… read more here.
Keywords: rnase rna; cleavage; specificity domain; rpr ... See more keywords
P18 (SRS35/TgSAG4) Plays a Role in the Invasion and Virulence of Toxoplasma gondii
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2021.643292
Abstract: Toxoplasmosis is a prevalent parasitic disease caused by Toxoplasma gondii (T. gondii). Under the control of the host immune system, T. gondii persists as latent bradyzoite cysts. Immunosuppression leads to their reactivation, a potentially life-threatening… read more here.
Keywords: invasion; toxoplasmosis; role; p18 ... See more keywords
Synthesis and Design of Purpurin-18-Loaded Solid Lipid Nanoparticles for Improved Anticancer Efficiency of Photodynamic Therapy
Sign Up to like & getrecommendations! Published in 2022 at "Pharmaceutics"
DOI: 10.3390/pharmaceutics14051064
Abstract: Purpurin-18 (P18) is one of the essential photosensitizers used in photodynamic therapy (PDT), but its hydrophobicity causes easy coalescence and poor bioavailability. This study aimed to synthesize P18 and design P18-loaded solid lipid nanoparticles (SLNs)… read more here.
Keywords: p18 loaded; slns; solid lipid; loaded solid ... See more keywords