Inhibition of RhoA and mTORC2/Rictor by Fingolimod (FTY720) induces p21-activated kinase 1, PAK-1 and amplifies podosomes in mouse peritoneal macrophages.
Sign Up to like & getrecommendations! Published in 2018 at "Immunobiology"
DOI: 10.1016/j.imbio.2018.07.009
Abstract: Macrophage functions in the immune response depend on their ability to infiltrate tissues and organs. The penetration between and within the tissues requires degradation of extracellular matrix (ECM), a function performed by the specialized, endopeptidase-… read more here.
Keywords: p21 activated; activated kinase; podosomes mouse; kinase pak ... See more keywords
p21-activated kinases as viable therapeutic targets for the treatment of high-risk Ewing sarcoma
Sign Up to like & getrecommendations! Published in 2021 at "Oncogene"
DOI: 10.1038/s41388-020-01600-9
Abstract: Ewing sarcoma (ES) is the second most common bone tumor in children and young adults. Unfortunately, there have been minimal recent advancements in improving patient outcomes, especially in metastatic and recurrent diseases. In this study,… read more here.
Keywords: p21 activated; risk; high risk; activated kinases ... See more keywords
A computational approach to explore and identify potential herbal inhibitors for the p21-activated kinase 1 (PAK1)
Sign Up to like & getrecommendations! Published in 2019 at "Journal of Biomolecular Structure and Dynamics"
DOI: 10.1080/07391102.2019.1659855
Abstract: Abstract The oncogenic kinase PAK1 (p21-activated kinase 1) is involved in developing many diseases including cancers, neurofibromatosis, Alzheimer's disease, diabetes (type 2), and hypertension. Thus, it is thought to be a prominent therapeutic target, and… read more here.
Keywords: p21 activated; kinase pak1; kinase; explore identify ... See more keywords
Targeting p21-activated kinase 4 (PAK4) with pyrazolo[3,4-d]pyrimidine derivative SPA7012 attenuates hepatic ischaemia-reperfusion injury in mice
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Enzyme Inhibition and Medicinal Chemistry"
DOI: 10.1080/14756366.2022.2106478
Abstract: Abstract p21-Activated kinase 4 (PAK4), one of the serine/threonine kinases activated by Rho-family GTPases, has been widely studied as an oncogenic protein that is overexpressed in many types of cancers. In our recent study, PAK4… read more here.
Keywords: mice; activated kinase; p21 activated; pak4 ... See more keywords
Role of activated p21-activated kinase 2 in methylmercury-induced embryotoxic effects on mouse blastocysts
Sign Up to like & getrecommendations! Published in 2023 at "Toxicology Research"
DOI: 10.1093/toxres/tfad030
Abstract: Methylmercury (MeHg), a biotransformation product derived from mercury or inorganic mercury compounds in waterways, is a potent toxin that exerts hazardous effects on human health via environmental contamination. Previous studies have reported MeHg-induced impairment of… read more here.
Keywords: development; methylmercury; kinase; pak2 ... See more keywords
Cardiac deficiency of P21-activated kinase 1 promotes atrial arrhythmogenesis in mice following adrenergic challenge
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0168
Abstract: P21-activated kinase 1 (Pak1) signalling plays a vital and overall protective role in the heart. However, the phenotypes of Pak1 deficiency in the cardiac atria have not been well explored. In this study, Pak1 cardiac-conditional… read more here.
Keywords: cko mice; activated kinase; p21 activated; mice ... See more keywords
Targeting p21-activated kinase 1 for development of a novel anti-arrhythmic drug class
Sign Up to like & getrecommendations! Published in 2023 at "Philosophical Transactions of the Royal Society B: Biological Sciences"
DOI: 10.1098/rstb.2022.0285
Abstract: Evidence accumulated over the past decade suggests that p21-activated kinase 1 (PAK1) is a critical cardiac-protective signalling molecule. The present article provides an updated review of recent findings regarding the role of PAK1 in maintaining… read more here.
Keywords: targeting p21; activated kinase; kinase development; p21 activated ... See more keywords
Phosphorylation-dependent activity-based conformational changes in P21-activated kinase family members and screening of novel ATP competitive inhibitors
Sign Up to like & getrecommendations! Published in 2019 at "PLoS ONE"
DOI: 10.1371/journal.pone.0225132
Abstract: P21-activated kinases (PAKs) are serine/threonine protein kinases that are subdivided into two groups on the basis of their domain architecture: group-I (PAK1–3) and group-II (PAK4–6). PAKs are considered as attractive drug targets that play vital… read more here.
Keywords: p21 activated; basis; atp competitive; family members ... See more keywords
p21-Activated Kinase 1 Promotes Breast Tumorigenesis via Phosphorylation and Activation of the Calcium/Calmodulin-Dependent Protein Kinase II
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2021.759259
Abstract: p21-Activated kinase-1 (Pak1) is frequently overexpressed and/or amplified in human breast cancer and is necessary for transformation of mammary epithelial cells. Here, we show that Pak1 interacts with and phosphorylates the Calcium/Calmodulin-dependent Protein Kinase II… read more here.
Keywords: activated kinase; kinase; breast cancer; calcium calmodulin ... See more keywords
The molecular basis of p21-activated kinase-associated neurodevelopmental disorders: From genotype to phenotype
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Neuroscience"
DOI: 10.3389/fnins.2023.1123784
Abstract: Although the identification of numerous genes involved in neurodevelopmental disorders (NDDs) has reshaped our understanding of their etiology, there are still major obstacles in the way of developing therapeutic solutions for intellectual disability (ID) and… read more here.
Keywords: neurodevelopmental disorders; basis p21; activated kinase; p21 activated ... See more keywords
Recent advances on development of p21-activated kinase 4 inhibitors as anti-tumor agents
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.956220
Abstract: The p21-activated kinase 4 (PAK4) is a member of the PAKs family. It is overexpressed in multiple tumor tissues. Pharmacological inhibition of PAK4 attenuates proliferation, migration, and invasion of cancer cells. Recent studies revealed that… read more here.
Keywords: development; activated kinase; pak4; p21 activated ... See more keywords