Methoxetamine Induces Cytotoxicity in H9c2 Cells: Possible Role of p21 Protein (Cdc42/Rac)-Activated Kinase 1
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DOI: 10.1007/s12012-018-9489-4
Abstract: The abuse of new psychoactive substances (NPS) is an emerging social problem. Methoxetamine, one of the NPS, was designed as an alternative to ketamine and it was considered an NPS candidate owing to its high… read more here.
Keywords: methoxetamine; h9c2 cells; protein cdc42; p21 protein ... See more keywords
p21 protein‐activated kinase 1 is associated with severe regressive autism, and epilepsy
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DOI: 10.1111/cge.13618
Abstract: The p21‐activated kinase (PAK) family of proteins function as key effectors of RHO family GTPases in mammalian cells to regulate many pathways including Ras/Raf/MEK/ERK and Wnt/β‐catenin, amongst others. Here we report an individual with a… read more here.
Keywords: regressive autism; severe regressive; p21 protein; activated kinase ... See more keywords
Peptides That Block RAS-p21 Protein-Induced Cell Transformation
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DOI: 10.3390/biomedicines11020471
Abstract: This is a review of approaches to the design of peptides and small molecules that selectively block the oncogenic RAS-p21 protein in ras-induced cancers. Single amino acid substitutions in this protein, at critical positions such… read more here.
Keywords: cell; oncogenic ras; p21 protein; block ras ... See more keywords