Inhibition of MDA‐MB‐231 breast cancer cell proliferation and tumor growth by apigenin through induction of G2/M arrest and histone H3 acetylation‐mediated p21WAF1/CIP1 expression
Sign Up to like & getrecommendations! Published in 2017 at "Environmental Toxicology"
DOI: 10.1002/tox.22247
Abstract: Apigenin (4′,5,7‐trihydroxyflavone), a flavonoid commonly found in fruits and vegetables, has anticancer properties in various malignant cancer cells. However, the molecular basis of the anticancer effect remains to be elucidated. In this study, we investigated… read more here.
Keywords: p21waf1 cip1; apigenin; breast cancer; cell ... See more keywords
NCOA5 deficiency promotes a unique liver protumorigenic microenvironment through p21WAF1/CIP1 overexpression, which is reversed by metformin
Sign Up to like & getrecommendations! Published in 2020 at "Oncogene"
DOI: 10.1038/s41388-020-1256-x
Abstract: Prevention and treatment options for hepatocellular carcinoma (HCC) are presently limited, underscoring the necessity for further elucidating molecular mechanisms underlying HCC development and identifying new prevention and therapeutic targets. Here, we demonstrate a unique protumorigenic… read more here.
Keywords: cip1 overexpression; p21waf1 cip1; cip1; protumorigenic microenvironment ... See more keywords
Mutational signatures reveal the role of RAD52 in p53-independent p21-driven genomic instability
Sign Up to like & getrecommendations! Published in 2018 at "Genome Biology"
DOI: 10.1186/s13059-018-1401-9
Abstract: BackgroundGenomic instability promotes evolution and heterogeneity of tumors. Unraveling its mechanistic basis is essential for the design of appropriate therapeutic strategies. In a previous study, we reported an unexpected oncogenic property of p21WAF1/Cip1, showing that… read more here.
Keywords: genomic instability; p21waf1 cip1; p53; mutational signatures ... See more keywords
Abnormal expression of cortical cell cycle regulators underlying anxiety and depressive-like behavior in mice exposed to chronic stress
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2022.999303
Abstract: Background The cell cycle is a critical mechanism for proper cellular growth, development and viability. The p16INK4a and p21Waf1/Cip1 are important regulators of the cell cycle progression in response to internal and external stimuli (e.g.,… read more here.
Keywords: stress; p21waf1 cip1; cell cycle; expression ... See more keywords