Subcellular localization of the FLT3-ITD oncogene plays a significant role in the production of NOX- and p22phox-derived reactive oxygen species in acute myeloid leukemia.
Sign Up to like & getrecommendations! Published in 2017 at "Leukemia research"
DOI: 10.1016/j.leukres.2016.11.006
Abstract: Internal tandem duplication of the juxtamembrane domain of FMS-like tyrosine kinase 3 (FLT3-ITD) receptor is the most prevalent FLT3 mutation accounting for 20% of acute myeloid leukemia (AML) patients. FLT3-ITD mutation results in ligand-independent constitutive… read more here.
Keywords: production; p22phox; flt3; acute myeloid ... See more keywords
Characterization of missense mutations in the NADPH oxidase partner p22phox in the A22° subtype of chronic granulomatous disease
Sign Up to like & getrecommendations! Published in 2023 at "Microbiology and Immunology"
DOI: 10.1111/1348-0421.13051
Abstract: Defective superoxide production by NADPH oxidase 2 (Nox2) in phagocyte cells results in the development of chronic granulomatous disease (CGD), a hereditary disease characterized by recurrent and life‐threatening infections. The partner protein p22phox is a… read more here.
Keywords: chronic granulomatous; nadph oxidase; missense mutations; granulomatous disease ... See more keywords
The correlation of p22phox and chemosensitivity in EGFR-TKI resistant lung adenocarcinoma
Sign Up to like & getrecommendations! Published in 2019 at "Oncotarget"
DOI: 10.18632/oncotarget.26637
Abstract: Background Enhancing the chemosensitivity in the patients with epidermal growth factor receptor-tyrosine kinase inhibitor (EGFR-TKI) resistant lung adenocarcinoma (LUAD) is pivotal in achieving their successful therapeutic outcome. We aimed to explore the mechanisms regarding the… read more here.
Keywords: tki resistant; p22phox; chemosensitivity; egfr tki ... See more keywords
Inhibition of p22phox Suppresses Epithelial Ovarian Cancer Cell Proliferation and Tumorigenesis
Sign Up to like & getrecommendations! Published in 2021 at "Journal of Cancer"
DOI: 10.7150/jca.54163
Abstract: The aim of this study was to investigate the biological role and molecular mechanism of p22phox in epithelial ovarian cancer. Immunohistochemistry was employed to determine the p22phox expression level in epithelial ovarian cancer tissues. The… read more here.
Keywords: epithelial ovarian; p22phox; cell proliferation; ovarian cancer ... See more keywords