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Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204599
Abstract: P53 inactivation occurs in about 50% of human cancers, where p53‐driven p21 activity is devoid and p27 becomes essential for the establishment of the G1/S checkpoint upon DNA damage. Here, this work shows that the…
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Keywords:
p27;
lncrna limp27;
p53 defective;
dna damage ... See more keywords
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Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22490
Abstract: The tumor suppressor p27, which is a member of the Cip/Kip family of Cyclin‐dependent kinase inhibitory proteins (CKIs), controls anti‐proliferative events. The post‐translational addition of O‐GlcNAc to p27 occurs in HEK293T and HCC (hepatocellular carcinoma)…
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Keywords:
hepatocellular carcinoma;
cell proliferation;
regulates cell;
p27 ... See more keywords
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Published in 2019 at "Journal of General Plant Pathology"
DOI: 10.1007/s10327-019-00850-0
Abstract: Tomato infectious chlorosis virus (TICV) belongs to the genus Crinivirus in the family Closteroviridae. We used Agrobacterium co-infiltration leaf patch assays to investigate the suppression of RNA silencing by p27, which is encoded by TICV-RNA1…
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Keywords:
rna silencing;
infectious chlorosis;
chlorosis virus;
tomato infectious ... See more keywords
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Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0278-5
Abstract: A proposed mechanism underlying the effect of bacillus Calmette–Guérin (BCG) treatment for bladder cancer cells is as follows: BCG-induced crosslinking of cell-surface receptors results in the activation of signaling cascades, including cell-cycle regulators. However, the…
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Keywords:
p21 p27;
nuclear expression;
bcg;
p27 ... See more keywords
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Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.06.040
Abstract: Proteins carry out a wide range of functions that are tightly regulated in space and time. Protein phosphorylation is the most common post-translation modification of proteins and plays a key role in the regulation of…
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Keywords:
protein dynamics;
phosphorylation buried;
buried residues;
phosphorylation ... See more keywords
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Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.01.017
Abstract: p27 mediates cell cycle arrest by binding to and inhibiting cyclin-dependent kinase/cyclin complexes, but p27 can also contribute to pro-oncogenic signaling upon mislocalization to the cytoplasm. Cytoplasmic p27 stimulates cell migration by associating with RhoA…
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Keywords:
cell migration;
p27 rhoa;
p27;
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Published in 2018 at "Journal of Vascular Surgery"
DOI: 10.1016/j.jvs.2016.12.113
Abstract: Background Cyclin‐dependent kinase inhibitor 1B (p27Kip1) is a cell‐cycle inhibitor whose ‐838C>A single nucleotide polymorphism (rs36228499; hereafter called p27 SNP) has been associated with the clinical failure of peripheral vein grafts, but the functional effects…
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Keywords:
vein;
adventitial cells;
smooth muscle;
graft failure ... See more keywords
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Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0374-1
Abstract: Pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) is a tumor suppressor that catalyzes the de-phosphorylation of the AGC kinases, while p27 acts as a tumor suppressor that regulates cell cycle, apoptosis, and cell…
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Keywords:
phlpp2;
protein;
degradation;
bladder cancer ... See more keywords
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Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1817415116
Abstract: Significance PI3K is activated in over 60% of human cancers, mediating C-terminal p27 phosphorylation. This work reveals cooperation between PI3K and cJun pathways: p27 phosphorylation by PI3K-activated kinases stimulates p27/cJun corecruitment to chromatin and activation…
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Keywords:
tumor progression;
p27 phosphorylation;
p27 cjun;
drive ... See more keywords
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Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2017115118
Abstract: Significance Tumor development can depend on cell intrinsic dysfunction, but, in some cases, extrinsic factors are important drivers. Here, we established a genetically tractable model, demonstrating that the same gene is relevant both cell autonomously…
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Keywords:
sox2 required;
tumorigenesis;
required independently;
cell ... See more keywords
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Published in 2022 at "Cell cycle"
DOI: 10.1080/15384101.2022.2074623
Abstract: Bladder cancer (BC) is the most expensive cancer to manage on a per-patient basis, costing about $4 billion in total healthcare expenditure per annum in America alone. Therefore, identifying a natural compound for prevention of…
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Keywords:
p27;
effect;
human urothelial;
egf induced ... See more keywords