LncRNA LIMp27 Regulates the DNA Damage Response through p27 in p53‐Defective Cancer Cells
Sign Up to like & getrecommendations! Published in 2023 at "Advanced Science"
DOI: 10.1002/advs.202204599
Abstract: P53 inactivation occurs in about 50% of human cancers, where p53‐driven p21 activity is devoid and p27 becomes essential for the establishment of the G1/S checkpoint upon DNA damage. Here, this work shows that the… read more here.
Keywords: p27; lncrna limp27; p53 defective; dna damage ... See more keywords
Modification of p27 with O‐linked N‐acetylglucosamine regulates cell proliferation in hepatocellular carcinoma
Sign Up to like & getrecommendations! Published in 2017 at "Molecular Carcinogenesis"
DOI: 10.1002/mc.22490
Abstract: The tumor suppressor p27, which is a member of the Cip/Kip family of Cyclin‐dependent kinase inhibitory proteins (CKIs), controls anti‐proliferative events. The post‐translational addition of O‐GlcNAc to p27 occurs in HEK293T and HCC (hepatocellular carcinoma)… read more here.
Keywords: hepatocellular carcinoma; cell proliferation; regulates cell; p27 ... See more keywords
The p27 open reading frame of tomato infectious chlorosis virus encodes a suppressor of RNA silencing
Sign Up to like & getrecommendations! Published in 2019 at "Journal of General Plant Pathology"
DOI: 10.1007/s10327-019-00850-0
Abstract: Tomato infectious chlorosis virus (TICV) belongs to the genus Crinivirus in the family Closteroviridae. We used Agrobacterium co-infiltration leaf patch assays to investigate the suppression of RNA silencing by p27, which is encoded by TICV-RNA1… read more here.
Keywords: rna silencing; infectious chlorosis; chlorosis virus; tomato infectious ... See more keywords
Nuclear co-expression of p21 and p27 induced effective cell-cycle arrest in T24 cells treated with BCG
Sign Up to like & getrecommendations! Published in 2018 at "Cytotechnology"
DOI: 10.1007/s10616-018-0278-5
Abstract: A proposed mechanism underlying the effect of bacillus Calmette–Guérin (BCG) treatment for bladder cancer cells is as follows: BCG-induced crosslinking of cell-surface receptors results in the activation of signaling cascades, including cell-cycle regulators. However, the… read more here.
Keywords: p21 p27; nuclear expression; bcg; p27 ... See more keywords
Protein Dynamics Enables Phosphorylation of Buried Residues in Cdk2/Cyclin-A-Bound p27.
Sign Up to like & getrecommendations! Published in 2020 at "Biophysical journal"
DOI: 10.1016/j.bpj.2020.06.040
Abstract: Proteins carry out a wide range of functions that are tightly regulated in space and time. Protein phosphorylation is the most common post-translation modification of proteins and plays a key role in the regulation of… read more here.
Keywords: protein dynamics; phosphorylation buried; buried residues; phosphorylation ... See more keywords
Mapping Interactions between p27 and RhoA that Stimulate Cell Migration.
Sign Up to like & getrecommendations! Published in 2018 at "Journal of molecular biology"
DOI: 10.1016/j.jmb.2018.01.017
Abstract: p27 mediates cell cycle arrest by binding to and inhibiting cyclin-dependent kinase/cyclin complexes, but p27 can also contribute to pro-oncogenic signaling upon mislocalization to the cytoplasm. Cytoplasmic p27 stimulates cell migration by associating with RhoA… read more here.
Keywords: cell migration; p27 rhoa; p27;
A single nucleotide polymorphism of cyclin‐dependent kinase inhibitor 1B (p27Kip1) associated with human vein graft failure affects growth of human venous adventitial cells but not smooth muscle cells
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Vascular Surgery"
DOI: 10.1016/j.jvs.2016.12.113
Abstract: Background Cyclin‐dependent kinase inhibitor 1B (p27Kip1) is a cell‐cycle inhibitor whose ‐838C>A single nucleotide polymorphism (rs36228499; hereafter called p27 SNP) has been associated with the clinical failure of peripheral vein grafts, but the functional effects… read more here.
Keywords: vein; adventitial cells; smooth muscle; graft failure ... See more keywords
PHLPP2 stabilization by p27 mediates its inhibition of bladder cancer invasion by promoting autophagic degradation of MMP2 protein
Sign Up to like & getrecommendations! Published in 2018 at "Oncogene"
DOI: 10.1038/s41388-018-0374-1
Abstract: Pleckstrin homology domain leucine-rich repeat protein phosphatase 2 (PHLPP2) is a tumor suppressor that catalyzes the de-phosphorylation of the AGC kinases, while p27 acts as a tumor suppressor that regulates cell cycle, apoptosis, and cell… read more here.
Keywords: phlpp2; protein; degradation; bladder cancer ... See more keywords
Non-canonical deubiquitination of OTUB1 induces IFNγ-mediated cell cycle arrest via regulation of p27 stability
Sign Up to like & getrecommendations! Published in 2024 at "Oncogene"
DOI: 10.1038/s41388-024-03042-z
Abstract: The deubiquitinase OTUB1, implicated as a potential oncogene in various tumors, lacks clarity in its regulatory mechanism in tumor progression. Our study investigated the effects and underlying mechanisms of OTUB1 on the breast cancer cell… read more here.
Keywords: p27; cell cycle; cycle arrest; otub1 ... See more keywords
p27 transcriptionally coregulates cJun to drive programs of tumor progression
Sign Up to like & getrecommendations! Published in 2019 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.1817415116
Abstract: Significance PI3K is activated in over 60% of human cancers, mediating C-terminal p27 phosphorylation. This work reveals cooperation between PI3K and cJun pathways: p27 phosphorylation by PI3K-activated kinases stimulates p27/cJun corecruitment to chromatin and activation… read more here.
Keywords: tumor progression; p27 phosphorylation; p27 cjun; drive ... See more keywords
SOX2 is required independently in both stem and differentiated cells for pituitary tumorigenesis in p27-null mice
Sign Up to like & getrecommendations! Published in 2021 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2017115118
Abstract: Significance Tumor development can depend on cell intrinsic dysfunction, but, in some cases, extrinsic factors are important drivers. Here, we established a genetically tractable model, demonstrating that the same gene is relevant both cell autonomously… read more here.
Keywords: sox2 required; tumorigenesis; required independently; cell ... See more keywords