FAK in the nucleus prevents VSMC proliferation by promoting p27 and p21 expression via Skp2 degradation.
Sign Up to like & getrecommendations! Published in 2021 at "Cardiovascular research"
DOI: 10.1093/cvr/cvab132
Abstract: AIM Vascular smooth muscle cells (VSMCs) normally exhibit a very low proliferative rate. Vessel injury triggers VSMC proliferation, in part, through focal adhesion kinase (FAK) activation, which increases transcription of cyclin D1, a key activator… read more here.
Keywords: degradation; skp2; fak; proliferation ... See more keywords