p27 transcriptionally coregulates cJun to drive programs of tumor progression
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DOI: 10.1073/pnas.1817415116
Abstract: Significance PI3K is activated in over 60% of human cancers, mediating C-terminal p27 phosphorylation. This work reveals cooperation between PI3K and cJun pathways: p27 phosphorylation by PI3K-activated kinases stimulates p27/cJun corecruitment to chromatin and activation… read more here.
Keywords: tumor progression; p27 phosphorylation; p27 cjun; drive ... See more keywords