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   Articles with "p27kip1" as a keyword



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The cyclin‐dependent kinase inhibitor p27Kip1 interacts with the aryl hydrocarbon receptor and negatively regulates its transcriptional activity

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recommendations! Published in 2022 at "FEBS Letters"

DOI: 10.1002/1873-3468.14434

Abstract: p27Kip1 functions to coordinate cell cycle progression through the inhibition of cyclin‐dependent kinase (CDK) complexes. p27Kip1 also exerts distinct activities beyond CDK‐inhibition, including functioning as a transcriptional regulator. The aryl hydrocarbon receptor (AhR) is a… read more here.

Keywords: hydrocarbon receptor; p27kip1; dependent kinase; cyclin dependent ... See more keywords
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Mathematical description of the interactions of CycE/Cdk2, Cdc25A, and P27Kip1 in a core cancer subnetwork

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recommendations! Published in 2017 at "Mathematical Methods in The Applied Sciences"

DOI: 10.1002/mma.4213

Abstract: Recent studies have shown that the initiation of human cancer is due to the malfunction of some genes (such as E2F, CycE, CycD, Cdc25A, P27Kip1, and Rb) at the R-checkpoint during the G1-to-S transition of… read more here.

Keywords: p27kip1; cancer subnetwork; cancer; cyce cdk2 ... See more keywords
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p27Kip1 Modulates Axonal Transport by Regulating α-Tubulin Acetyltransferase 1 Stability.

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recommendations! Published in 2018 at "Cell reports"

DOI: 10.1016/j.celrep.2018.04.083

Abstract: The protein p27Kip1 plays roles that extend beyond cell-cycle regulation during cerebral cortex development, such as the regulation of neuronal migration and neurite branching via signaling pathways that converge on the actin and microtubule cytoskeletons.… read more here.

Keywords: tubulin acetyltransferase; transport; p27kip1; p27kip1 modulates ... See more keywords
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Chromosome region maintenance-1 (CRM1) regulates apoptosis of intestinal epithelial cells via p27kip1 in Crohn's disease.

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recommendations! Published in 2017 at "Clinics and research in hepatology and gastroenterology"

DOI: 10.1016/j.clinre.2017.01.012

Abstract: OBJECTIVE To investigate the role of chromosome region maintenance-1 (CRM1) in Crohn's disease (CD) and its potential pathological mechanisms. METHODS The expression and distribution of CRM1 in mucosal biopsies from patients with active CD and… read more here.

Keywords: caspase cleaved; active caspase; p27kip1; expression ... See more keywords

Cip2a promotes cell cycle progression in triple-negative breast cancer cells by regulating the expression and nuclear export of p27Kip1

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recommendations! Published in 2017 at "Oncogene"

DOI: 10.1038/onc.2016.355

Abstract: Triple-negative breast cancer (TNBC) is very aggressive and currently has no specific therapeutic targets; as a consequence, TNBC exhibits poor clinical outcome. In this study, we showed that cancerous inhibitor of protein phosphatase 2A (Cip2a)… read more here.

Keywords: cell cycle; cip2a; p27kip1; tnbc ... See more keywords
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WIP1 dephosphorylation of p27Kip1 Serine 140 destabilizes p27Kip1 and reverses anti-proliferative effects of ATM phosphorylation

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recommendations! Published in 2020 at "Cell Cycle"

DOI: 10.1080/15384101.2020.1717025

Abstract: ABSTRACT The phosphoinositide-3-kinase like kinases (PIKK) such as ATM and ATR play a key role in initiating the cellular DNA damage response (DDR). One key ATM target is the cyclin-dependent kinase inhibitor p27Kip1 that promotes… read more here.

Keywords: p27kip1; p27kip1 serine; serine 140; wip1 ... See more keywords
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HMGA2 drives the IGFBP1/AKT pathway to counteract the increase in P27KIP1 protein levels in mtDNA/RNA‐less cancer cells

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recommendations! Published in 2022 at "Cancer Science"

DOI: 10.1111/cas.15582

Abstract: Recent comprehensive analyses of mtDNA and orthogonal RNA‐sequencing data revealed that in numerous human cancers, mtDNA copy numbers and mtRNA amounts are significantly reduced, followed by low respiratory gene expression. Under such conditions (called mt‐Low),… read more here.

Keywords: cell proliferation; p27kip1; increase p27kip1; igfbp1 akt ... See more keywords
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Akt/p27kip1 Pathway Is Not Involved in Human Insulinoma Tumorigenesis

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recommendations! Published in 2018 at "International Journal of Endocrinology"

DOI: 10.1155/2018/7865072

Abstract: Insulinomas are pancreatic neuroendocrine tumors (pNET), usually benign. Akt/p27kip1 is an intracellular pathway overexpressed in many pNET. There are no data regarding its expression in human insulinomas. We aimed to investigate the expression of Akt… read more here.

Keywords: insulinomas; pathway involved; p27kip1; expression ... See more keywords
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LncRNA GAS5 Inhibits Cellular Proliferation by Targeting P27Kip1

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recommendations! Published in 2017 at "Molecular Cancer Research"

DOI: 10.1158/1541-7786.mcr-16-0331

Abstract: Recent studies have demonstrated that long noncoding RNAs (lncRNA) have important roles in cancer biology, and that the downregulation of lncRNA growth arrest–specific transcript 5 (GAS5) has been reported in a variety of human cancers.… read more here.

Keywords: gas5; prostate cancer; proliferation; p27kip1 ... See more keywords