Identification of rs11615992 as a novel regulatory SNP for human P2RX7 by allele-specific expression
Sign Up to like & getrecommendations! Published in 2019 at "Molecular Genetics and Genomics"
DOI: 10.1007/s00438-019-01598-0
Abstract: P2RX7 (purinergic receptor P2X 7) is an important membrane ion channel and involved in multiple physiological processes. One non-synonymous SNP on P2RX7, rs3751143, had been proven to reduce ion channel function and further associated with… read more here.
Keywords: specific expression; p2rx7; snp; allele specific ... See more keywords
P2RX7 Purinoceptor as a Therapeutic Target—The Second Coming?
Sign Up to like & getrecommendations! Published in 2018 at "Frontiers in Chemistry"
DOI: 10.3389/fchem.2018.00248
Abstract: The P2RX7 receptor is a unique member of a family of extracellular ATP (eATP)-gated ion channels expressed in immune cells, where its activation triggers the inflammatory cascade. Therefore, P2RX7 has been long investigated as a… read more here.
Keywords: purinoceptor therapeutic; target; p2rx7; p2rx7 purinoceptor ... See more keywords
P2RX7 in Dopaminergic Neurons of Ventral Periaqueductal Gray Mediates HTWP Acupuncture-Induced Consciousness in Traumatic Brain Injury
Sign Up to like & getrecommendations! Published in 2020 at "Frontiers in Cellular Neuroscience"
DOI: 10.3389/fncel.2020.598198
Abstract: The induction of a coma by traumatic brain injury (TBI) is a crucial factor for poor clinical prognoses. We report that acupuncture at the hand 12 Jing-Well points (HTWP) improved consciousness and neurologic function in… read more here.
Keywords: traumatic brain; acupuncture; ventral periaqueductal; p2rx7 ... See more keywords