P2RY14 downregulation in lung adenocarcinoma: a potential therapeutic target associated with immune infiltration
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Thoracic Disease"
DOI: 10.21037/jtd-22-115
Abstract: Background The current study aimed to investigate the interrelation between P2RY14 and the prognosis of patients suffering from lung adenocarcinoma (LUAD) following surgery. Methods The differentially expressed gene (DEG) P2RY14 was screened by the Gene… read more here.
Keywords: p2ry14; lung adenocarcinoma; p2ry14 expression; expression ... See more keywords
Reduced urine volume and changed renal sphingolipid metabolism in P2ry14-deficient mice
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Cell and Developmental Biology"
DOI: 10.3389/fcell.2023.1128456
Abstract: The UDP-glucose receptor P2RY14, a rhodopsin-like G protein-coupled receptor (GPCR), was previously described as receptor expressed in A-intercalated cells of the mouse kidney. Additionally, we found P2RY14 is abundantly expressed in mouse renal collecting duct… read more here.
Keywords: p2ry14; sphingolipid metabolism; reduced urine; mice ... See more keywords
P2RY14 cAMP signaling regulates Schwann cell precursor self-renewal, proliferation, and nerve tumor initiation in a mouse model of neurofibromatosis
Sign Up to like & getrecommendations! Published in 2022 at "eLife"
DOI: 10.7554/elife.73511
Abstract: Neurofibromatosis type 1 (NF1) is characterized by nerve tumors called neurofibromas, in which Schwann cells (SCs) show deregulated RAS signaling. NF1 is also implicated in regulation of cAMP. We identified the G-protein-coupled receptor (GPCR) P2ry14… read more here.
Keywords: mouse; self renewal; p2ry14; camp ... See more keywords