Modulation of innate and adaptive immunity by P2X ion channels.
Sign Up to like & getrecommendations! Published in 2018 at "Current opinion in immunology"
DOI: 10.1016/j.coi.2018.03.026
Abstract: Extracellular ATP is a major component of the inflammatory microenvironment where it accumulates following cell and tissue injury but also as a consequence of non-lytic release from activated inflammatory cells. In the inflammatory microenvironment ATP… read more here.
Keywords: p2x; ion; adaptive immunity; innate adaptive ... See more keywords
Role of the purinergic P2X receptors in osteoclast pathophysiology.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2019.02.013
Abstract: Osteoclasts are cells of the hematopoietic lineage that are responsible for bone resorption. Their activity is crucial in the initiation of bone remodeling and for maintenance of a strong and healthy skeleton. However, in a… read more here.
Keywords: p2x receptors; p2x; bone; role ... See more keywords
Physiological contribution of P2X receptors in postreceptoral signal processing in the mouse retina
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Research"
DOI: 10.1016/j.neures.2016.09.012
Abstract: ATP activates P2X receptors and acts as a neurotransmitter in the nervous system. We have previously reported that P2X receptors modulate the firing rate of retinal ganglion cells. Since many subtypes of P2X receptors are… read more here.
Keywords: p2x receptors; intravitreal injection; p2x; mouse retina ... See more keywords
P2X receptors up-regulate the cell-surface expression of the neuronal glycine transporter GlyT2
Sign Up to like & getrecommendations! Published in 2017 at "Neuropharmacology"
DOI: 10.1016/j.neuropharm.2017.07.018
Abstract: Glycinergic inhibitory neurons of the spinal dorsal horn exert critical control over the conduction of nociceptive signals to higher brain areas. The neuronal glycine transporter 2 (GlyT2) is involved in the recycling of synaptic glycine… read more here.
Keywords: p2x; glycine transporter; expression; neuronal glycine ... See more keywords
Cross-Talk between P2X and NMDA Receptors
Sign Up to like & getrecommendations! Published in 2020 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms21197187
Abstract: Purinergic P2X receptors (P2X) are ATP-gated ion channels widely expressed in the CNS. While the direct contribution of P2X to synaptic transmission is uncertain, P2X reportedly affect N-methyl-D-aspartate receptor (NMDAR) activity, which has given rise… read more here.
Keywords: cross talk; p2x2 p2x4; p2x; talk p2x ... See more keywords
Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126585
Abstract: P2X receptors belong to a family of cation channel proteins, which respond to extracellular adenosine 5′-triphosphate (ATP). These receptors have gained increasing attention in basic and translational research, as they are central to a variety… read more here.
Keywords: platelets role; receptors nociception; p2x receptors; p2x ... See more keywords