P2X Receptor Activation.
Sign Up to like & getrecommendations! Published in 2017 at "Advances in experimental medicine and biology"
DOI: 10.1007/5584_2017_55
Abstract: Extracellular ATP-gated P2X receptors are trimeric non-selective cation channels important for many physiological events including immune response and neural transmission. These receptors belong to a unique class of ligand-gated ion channels composed of only six… read more here.
Keywords: receptor activation; p2x receptor; pharmacology;
Role of opioid receptors in modulation of P2X receptor-mediated cardiac sympathoexcitatory reflex response
Sign Up to like & getrecommendations! Published in 2019 at "Scientific Reports"
DOI: 10.1038/s41598-019-53754-6
Abstract: Myocardial ischemia evokes powerful reflex responses through activation of vagal and sympathetic afferents in the heart through the release of ischemic metabolites. We have demonstrated that extracellular ATP stimulates cardiac sympathetic afferents through P2 receptor-mediated… read more here.
Keywords: p2x receptor; csr responses; cardiac sympathoexcitatory; receptor ... See more keywords
P2X receptor antagonists and their potential as therapeutics: a patent review (2010–2021)
Sign Up to like & getrecommendations! Published in 2022 at "Expert Opinion on Therapeutic Patents"
DOI: 10.1080/13543776.2022.2069010
Abstract: ABSTRACT Introduction Purinergic receptors play a critical role in neurotransmission, and modulation of complex physiological functions and thus have implications in numerous disease states. The past decade has seen substantial progress in the design of… read more here.
Keywords: review; receptor antagonists; p2x receptor; patent ... See more keywords