Heterologous Expression and Patch-Clamp Recording of P2X Receptors in HEK293 Cells.
Sign Up to like & getrecommendations! Published in 2020 at "Methods in molecular biology"
DOI: 10.1007/978-1-4939-9717-6_19
Abstract: P2X receptors (P2XRs) are ligand-gated ion channels gated by extracellular adenosine 5'-triphosphate (ATP) and play a critical role in mediating ATP-induced purinergic signaling in physiological and pathological processes. Heterologous expression of P2XR in human embryonic… read more here.
Keywords: p2x receptors; patch clamp; hek293 cells; clamp recording ... See more keywords
Physiological Concentrations of Zinc Have Dual Effects on P2X Myenteric Receptors of Guinea Pig
Sign Up to like & getrecommendations! Published in 2018 at "Cellular and Molecular Neurobiology"
DOI: 10.1007/s10571-018-0612-7
Abstract: We, hereby, characterize the pharmacological effects of physiological concentrations of Zinc on native myenteric P2X receptors from guinea-pig small intestine and on P2X2 isoforms present in most myenteric neurons. This is the first study describing… read more here.
Keywords: p2x myenteric; p2x receptors; physiological concentrations; effect ... See more keywords
Role of the purinergic P2X receptors in osteoclast pathophysiology.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2019.02.013
Abstract: Osteoclasts are cells of the hematopoietic lineage that are responsible for bone resorption. Their activity is crucial in the initiation of bone remodeling and for maintenance of a strong and healthy skeleton. However, in a… read more here.
Keywords: p2x receptors; p2x; bone; role ... See more keywords
Physiological contribution of P2X receptors in postreceptoral signal processing in the mouse retina
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience Research"
DOI: 10.1016/j.neures.2016.09.012
Abstract: ATP activates P2X receptors and acts as a neurotransmitter in the nervous system. We have previously reported that P2X receptors modulate the firing rate of retinal ganglion cells. Since many subtypes of P2X receptors are… read more here.
Keywords: p2x receptors; intravitreal injection; p2x; mouse retina ... See more keywords
Structural insights into the competitive inhibition of the ATP-gated P2X receptor channel
Sign Up to like & getrecommendations! Published in 2017 at "Nature Communications"
DOI: 10.1038/s41467-017-00887-9
Abstract: P2X receptors are non-selective cation channels gated by extracellular ATP, and the P2X7 receptor subtype plays a crucial role in the immune and nervous systems. Altered expression and dysfunctions of P2X7 receptors caused by genetic… read more here.
Keywords: p2x receptors; atp; inhibition; structure ... See more keywords
Activated P2X receptors can up-regulate the expressions of inflammation-related genes via NF-κB pathway in spotted sea bass (Lateolabrax maculatus)
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2023.1181067
Abstract: P2X receptors, including seven subtypes, i.e., P2X1-7, are the ligand-gated ion channels activated by the extracellular ATP playing the critical roles in inflammation and immune response. Even though the immune functions of P2X receptors have… read more here.
Keywords: sea bass; spotted sea; p2x receptors; expressions inflammation ... See more keywords
P2X Receptors: Potential Therapeutic Targets for Symptoms Associated With Lung Cancer — A Mini Review
Sign Up to like & getrecommendations! Published in 2021 at "Frontiers in Oncology"
DOI: 10.3389/fonc.2021.691956
Abstract: Symptoms associated with lung cancer mainly consist of cancer-associated pain, cough, fatigue, and dyspnea. However, underlying mechanisms of lung cancer symptom clusters remain unclear. There remains a paucity of effective treatment to ameliorate debilitating symptoms… read more here.
Keywords: cancer; p2x receptors; oncology; lung cancer ... See more keywords
Molecular Pharmacology of P2X Receptors: Exploring Druggable Domains Revealed by Structural Biology
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2022.925880
Abstract: Extracellular ATP is a critical signaling molecule that is found in a wide range of concentrations across cellular environments. The family of nonselective cation channels that sense extracellular ATP, termed P2X receptors (P2XRs), is composed… read more here.
Keywords: structural biology; pharmacology; p2x receptors; extracellular atp ... See more keywords
Platelets and the Role of P2X Receptors in Nociception, Pain, Neuronal Toxicity and Thromboinflammation
Sign Up to like & getrecommendations! Published in 2022 at "International Journal of Molecular Sciences"
DOI: 10.3390/ijms23126585
Abstract: P2X receptors belong to a family of cation channel proteins, which respond to extracellular adenosine 5′-triphosphate (ATP). These receptors have gained increasing attention in basic and translational research, as they are central to a variety… read more here.
Keywords: platelets role; receptors nociception; p2x receptors; p2x ... See more keywords