Variable transcriptional responsiveness of the P2X3 receptor gene during CFA‐induced inflammatory hyperalgesia
Sign Up to like & getrecommendations! Published in 2018 at "Journal of Cellular Biochemistry"
DOI: 10.1002/jcb.26534
Abstract: The purinergic receptor P2X3 (P2X3‐R) plays important roles in molecular pathways of pain, and reduction of its activity or expression effectively reduces chronic inflammatory and neuropathic pain sensation. Inflammation, nerve injury, and cancer‐induced pain can… read more here.
Keywords: p2x3; inflammatory hyperalgesia; cfa; receptor ... See more keywords
Knockdown the P2X3 receptor in the stellate ganglia of rats relieved the diabetic cardiac autonomic neuropathy
Sign Up to like & getrecommendations! Published in 2018 at "Neurochemistry International"
DOI: 10.1016/j.neuint.2018.09.002
Abstract: &NA; Diabetic cardiac autonomic neuropathy (DCAN) is a common and serious complication of diabetes mellitus (DM), is manifested by nerve fiber injury in the sympathetic and parasympathetic nerve of the autonomic nervous system, and causes… read more here.
Keywords: p2x3 shrna; p2x3; heart rate; p2x3 receptor ... See more keywords
Activation of P2X3 receptors in the cerebrospinal fluid-contacting nucleus neurons reduces formalin-induced pain behavior via PAG in a rat model
Sign Up to like & getrecommendations! Published in 2017 at "Neuroscience"
DOI: 10.1016/j.neuroscience.2017.06.036
Abstract: The cerebrospinal fluid (CSF)-contacting nucleus is implicated in the descending inhibitory pathway in pain processing, whereas the cellular and molecular mechanisms underpinning CSF-contacting nucleus regulating pain signals remains largely elusive. ATP is evidenced to inhibit… read more here.
Keywords: p2x3; p2x3 receptors; rat model; contacting nucleus ... See more keywords
Investigation on 2',3'-O-Substituted ATP Derivatives and Analogs as Novel P2X3 Receptor Antagonists.
Sign Up to like & getrecommendations! Published in 2019 at "ACS medicinal chemistry letters"
DOI: 10.1021/acsmedchemlett.8b00524
Abstract: Antagonists of the purinergic P2X3 receptors represent promising drugs for the treatment of inflammation and pain. The ATP derivative 2',3'-O-(2,4,6-trinitrophenyl)-ATP (TNP-ATP) has been described as a potent competitive inhibitor of this receptor. In this work,… read more here.
Keywords: investigation substituted; receptor; p2x3; p2x3 receptor ... See more keywords
P2X3-P2X7 SNPs and gene-gene and gene-environment interactions on pediatric asthma
Sign Up to like & getrecommendations! Published in 2022 at "Journal of Asthma"
DOI: 10.1080/02770903.2022.2155184
Abstract: Abstract Background To investigate the relationship between polymorphisms of P2X3, P2X7 genes and environment interaction with susceptibility of childhood asthma. Methods We conducted a matched case-control study with 170 cases and 175 healthy controls. The… read more here.
Keywords: environment; gene gene; p2x3; asthma ... See more keywords
Bone marrow-derived mesenchymal stem cells attenuate complete Freund's adjuvant-induced inflammatory pain by inhibiting the expression of P2X3.
Sign Up to like & getrecommendations! Published in 2023 at "Cell proliferation"
DOI: 10.1111/cpr.13461
Abstract: Bone marrow-derived mesenchymal stem cells (BMSCs) show a good property for pain treatment by modulating inflammatory response. However, the underlying therapeutic effect and related mechanism of BMSCs on inflammatory pain remain unclear. Therefore, we explored… read more here.
Keywords: p2x3; derived mesenchymal; bone marrow; marrow derived ... See more keywords
Variability in P2X receptor composition in human taste nerves: implications for treatment of chronic cough
Sign Up to like & getrecommendations! Published in 2023 at "ERJ Open Research"
DOI: 10.1183/23120541.00007-2023
Abstract: Background Antagonists to the P2X purinergic receptors on airway sensory nerves relieve refractory or unexplained chronic cough (RCC/UCC) but can evoke unwanted dysgeusias because the gustatory nerves innervating taste buds express this same family of… read more here.
Keywords: p2x3; chronic cough; composition; taste ... See more keywords
TNF-α enhances sensory DRG neuron excitability through modulation of P2X3 receptors in an acute colitis model
Sign Up to like & getrecommendations! Published in 2022 at "Frontiers in Immunology"
DOI: 10.3389/fimmu.2022.872760
Abstract: Previous studies have demonstrated that acute colonic inflammation leads to an increase in dorsal root ganglia (DRG) neuronal excitability. However, the signaling elements implicated in this hyperexcitability have yet to be fully unraveled. Extracellular adenosine… read more here.
Keywords: p2x3; p2x3 receptor; excitability; tnf enhances ... See more keywords