Implication of Neuronal Versus Microglial P2X4 Receptors in Central Nervous System Disorders.
Sign Up to like & getrecommendations! Published in 2020 at "Neuroscience bulletin"
DOI: 10.1007/s12264-020-00570-y
Abstract: The P2X4 receptor (P2X4) is an ATP-gated cation channel that is highly permeable to Ca2+ and widely expressed in neuronal and glial cell types throughout the central nervous system (CNS). A growing body of evidence… read more here.
Keywords: implication neuronal; neuronal versus; nervous system; central nervous ... See more keywords
Characterization of P2X4 receptor agonists and antagonists by calcium influx and radioligand binding studies
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DOI: 10.1016/j.bcp.2016.11.016
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Antagonists for ATPâactivated P2X4 ion channel receptors are currently in the focus as novel drug targets, in particular for the treatment of neuropathic and inflammatory pain. We stably… read more here.
Keywords: radioligand binding; p2x4 receptor; p2x4; binding studies ... See more keywords
The mechanism by which ATP regulates alcoholic steatohepatitis through P2X4 and CD39.
Sign Up to like & getrecommendations! Published in 2021 at "European journal of pharmacology"
DOI: 10.1016/j.ejphar.2021.174729
Abstract: Alcoholic liver disease caused by chronic excessive drinking has become one of the most common types of liver disease. Alcohol-induced inflammatory immune responses play a central role in the development of alcohol-associated steatohepatitis. The content… read more here.
Keywords: expression; cd39; p2x4; atp ... See more keywords
P2x4 receptor promotes mammary cancer progression by sustaining autophagy and associated mesenchymal transition
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DOI: 10.1038/s41388-022-02297-8
Abstract: Metastatic progression is a major burden for breast cancer patients and is associated with the ability of cancer cells to overcome stressful conditions, such as nutrients deprivation and hypoxia, and to gain invasive properties. Autophagy… read more here.
Keywords: p2x4; cancer progression; mesenchymal transition; cancer ... See more keywords
Extracellular ATP Induces Calcium Signaling in Odontoblasts
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DOI: 10.1177/0022034516671308
Abstract: Odontoblasts form dentin at the outermost surface of tooth pulp. An increasing level of evidence in recent years, along with their locational advantage, implicates odontoblasts as a secondary role as sensory or immune cells. Extracellular… read more here.
Keywords: atp; response; extracellular atp; p2x4 ... See more keywords
P2X4 receptors mediate induction of antioxidants, fibrogenic cytokines and ECM transcripts; in presence of replicating HCV in in vitro setting: An insight into role of P2X4 in fibrosis
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DOI: 10.1371/journal.pone.0259727
Abstract: Background & aims Major HCV infections lead to chronic hepatitis, which results in progressive liver disease including fibrosis, cirrhosis and eventually hepatocellular carcinoma (HCC). P2X4 and P2X7 are most widely distributed receptors on hepatocytes. Methods… read more here.
Keywords: day post; presence; control; hcv ... See more keywords
Neuronal P2X4 receptor may contribute to peripheral inflammatory pain in rat spinal dorsal horn
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Molecular Neuroscience"
DOI: 10.3389/fnmol.2023.1115685
Abstract: Objective Intense inflammation may result in pain, which manifests as spinal central sensitization. There is growing evidence that purinergic signaling plays a pivotal role in the orchestration of pain processing. Over the last decade the… read more here.
Keywords: spinal dorsal; inflammatory pain; pain; receptor ... See more keywords
Identification of a novel P2X7 antagonist using structure-based virtual screening
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DOI: 10.3389/fphar.2022.1094607
Abstract: P2X4 and P2X7 receptors are ATP-gated ion channels, which play important roles in neuropathic and inflammatory pain, and as such they are important drug targets in diseases of inflammatory origin. While several compounds targeting P2X4… read more here.
Keywords: human p2x7; using structure; p2x7; p2x4 ... See more keywords
Identification of the molecular determinants of antagonist potency in the allosteric binding pocket of human P2X4
Sign Up to like & getrecommendations! Published in 2023 at "Frontiers in Pharmacology"
DOI: 10.3389/fphar.2023.1101023
Abstract: P2X receptors are a family of ATP-gated cation channels comprising seven subtypes in mammals, which play key roles in nerve transmission, pain sensation and inflammation. The P2X4 receptor in particular has attracted significant interest from… read more here.
Keywords: bx430; allosteric pocket; pocket; human p2x4 ... See more keywords