Characterization of P2X4 receptor agonists and antagonists by calcium influx and radioligand binding studies
Sign Up to like & getrecommendations! Published in 2017 at "Biochemical Pharmacology"
DOI: 10.1016/j.bcp.2016.11.016
Abstract: Graphical abstract Figure. No Caption available. ABSTRACT Antagonists for ATP‐activated P2X4 ion channel receptors are currently in the focus as novel drug targets, in particular for the treatment of neuropathic and inflammatory pain. We stably… read more here.
Keywords: radioligand binding; p2x4 receptor; p2x4; binding studies ... See more keywords
Structure-Activity Relationship and Neuroprotective Activity of 1,5-Dihydro-2H-naphtho[1,2-b][1,4]diazepine-2,4(3H)-diones as P2X4 Receptor Antagonists.
Sign Up to like & getrecommendations! Published in 2022 at "Journal of medicinal chemistry"
DOI: 10.1021/acs.jmedchem.2c01197
Abstract: We analyzed the P2X4 receptor structure-activity relationship of a known antagonist 5, a 1,5-dihydro-2H-naphtho[1,2-b][1,4]diazepine-2,4(3H)-dione. Following extensive modification of the reported synthetic route, 4-pyridyl 21u (MRS4719) and 6-methyl 22c (MRS4596) analogues were most potent at human… read more here.
Keywords: structure activity; naphtho diazepine; activity relationship; activity ... See more keywords
The renal and blood pressure response to low sodium diet in P2X4 receptor knockout mice
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DOI: 10.14814/phy2.13899
Abstract: In the kidney, purinergic (P2) receptor‐mediated ATP signaling has been shown to be an important local regulator of epithelial sodium transport. Appropriate sodium regulation is crucial for blood pressure (BP) control and disturbances in sodium… read more here.
Keywords: p2x4 receptor; sodium; p2x4 mice; mice ... See more keywords
The mechanism behind activation of the Nod-like receptor family protein 3 inflammasome in Parkinson’s disease
Sign Up to like & getrecommendations! Published in 2022 at "Neural Regeneration Research"
DOI: 10.4103/1673-5374.323077
Abstract: Previous studies have shown that the ATP-P2X4 receptor signaling pathway mediates the activation of the Nod-like receptor family protein 3 (NLRP3) inflammasome. The NLRP3 inflammasome may promote renal interstitial inflammation in diabetic nephropathy. As inflammation… read more here.
Keywords: receptor; nlrp3 inflammasome; p2x4 receptor; parkinson disease ... See more keywords