The Anti‐Human P2X7 Monoclonal Antibody (Clone L4) Can Mediate Complement‐Dependent Cytotoxicity of Human Leukocytes
Sign Up to like & getrecommendations! Published in 2025 at "European Journal of Immunology"
DOI: 10.1002/eji.202451196
Abstract: P2X7 is an extracellular adenosine 5′‐triphosphate (ATP)‐gated cation channel that plays various roles in inflammation and immunity. P2X7 is present on peripheral blood monocytes, dendritic cells (DCs), and innate and adaptive lymphocytes. The anti‐human P2X7… read more here.
Keywords: p2x7; anti human; p2x7 monoclonal; antibody ... See more keywords
P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP
Sign Up to like & getrecommendations! Published in 2019 at "Purinergic Signalling"
DOI: 10.1007/s11302-019-09654-5
Abstract: ATP and its metabolites are important extracellular signal transmitters acting on purinergic P2 and P1 receptors. Most cells can actively secrete ATP in response to a variety of external stimuli such as gating of the… read more here.
Keywords: mediated atp; atp; p2x7 mediated; p2x7 ... See more keywords
Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization
Sign Up to like & getrecommendations! Published in 2019 at "Cell"
DOI: 10.1016/j.cell.2019.09.017
Abstract: P2X receptors are trimeric, non-selective cation channels activated by extracellular ATP. The P2X7 receptor subtype is a pharmacological target because of involvement in apoptotic, inflammatory, and tumor progression pathways. It is the most structurally and… read more here.
Keywords: full length; p2x7; structures reveal; receptor ... See more keywords
Novel biologics targeting the P2X7 ion channel.
Sign Up to like & getrecommendations! Published in 2019 at "Current opinion in pharmacology"
DOI: 10.1016/j.coph.2019.03.001
Abstract: Targeting the P2X7 ion channel, a danger sensor for extracellular nucleotides, improves outcomes in models of inflammation, cancer, and brain-diseases. Antibodies and nanobodies have been developed that antagonize or potentiate gating of P2X7. Their potential… read more here.
Keywords: p2x7; p2x7 ion; targeting p2x7; ion channel ... See more keywords
Inhibition of P2X7 receptor delays the progression of diabetic nephropathy and represses klotho expression
Sign Up to like & getrecommendations! Published in 2018 at "Free Radical Biology and Medicine"
DOI: 10.1016/j.freeradbiomed.2018.10.093
Abstract: Introduction Previous studies in our laboratory have suggested that P2X7 could contribute to the progression of diabetic nephropathy and modulate klotho expression. Aim of this study was to investigate the role of P2X7 knockdown in… read more here.
Keywords: p2x7; progression diabetic; diabetic nephropathy; klotho expression ... See more keywords
Identification of New Human P2X7 Antagonists Using Ligand- and Structure-Based Virtual Screening
Sign Up to like & getrecommendations! Published in 2025 at "Journal of Chemical Information and Modeling"
DOI: 10.1021/acs.jcim.5c00552
Abstract: P2X7 receptors, a subtype of ATP-gated cation channel, have gained attention due to their involvement in inflammatory and neurodegenerative diseases, chronic pain, and cancer. However, despite extensive medicinal chemistry efforts, no P2X7 antagonists have reached… read more here.
Keywords: p2x7; structure based; virtual screening; ligand ... See more keywords
Longitudinal Positron Emission Tomography Imaging with P2X7 Receptor-Specific Radioligand 18F-FTTM in a Kainic Acid Rat Model of Temporal Lobe Epilepsy.
Sign Up to like & getrecommendations! Published in 2022 at "ACS chemical neuroscience"
DOI: 10.1021/acschemneuro.2c00557
Abstract: P2X7 receptors (P2X7R), as a brain inflammation biomarker, play important roles in the epileptogenic progress. Mounting evidence supports their activation in the brain during epilepsy, and inhibition of the P2X7 receptor reduces the seizure frequency… read more here.
Keywords: p2x7 receptor; rat; p2x7; 18f fttm ... See more keywords
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
Sign Up to like & getrecommendations! Published in 2020 at "Molecular Psychiatry"
DOI: 10.1038/s41380-020-00965-3
Abstract: Scientists and health professionals are exhaustively trying to contain the coronavirus disease 2019 (COVID-19) pandemic by elucidating viral invasion mechanisms, possible drugs to prevent viral infection/replication, and health cares to minimize individual exposure. Although neurological… read more here.
Keywords: p2x7; hyperactivation p2x7; infection; p2x7 receptors ... See more keywords
P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice
Sign Up to like & getrecommendations! Published in 2020 at "Nature Communications"
DOI: 10.1038/s41467-020-15590-5
Abstract: Dysregulated immunity has been implicated in the pathogenesis of neurodevelopmental disorders but its contribution to synaptic and behavioral deficits in Rett syndrome (RTT) remains unknown. P2X7 receptors (P2X7Rs) are unique purinergic receptors with pro-inflammatory functions.… read more here.
Keywords: behavioral deficits; dendritic spine; p2x7; rett syndrome ... See more keywords
Understanding interspecies drug response variations between human and rodent P2X7 receptors
Sign Up to like & getrecommendations! Published in 2025 at "Nature Communications"
DOI: 10.1038/s41467-025-65847-0
Abstract: Despite intensive development, P2X7 modulators have struggled in translation due to human genetic variability and species-dependent drug responses. Here, we identify PSFL1191, a portal-of-central-pocket (PCP)-site inhibitor selective for human and panda P2X7, but inactive against… read more here.
Keywords: p2x7; drug response; understanding interspecies; drug ... See more keywords
Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells
Sign Up to like & getrecommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"
DOI: 10.1073/pnas.2119286119
Abstract: Significance The extracellular concentration of adenosine triphosphate (ATP) reaches several hundred micromoles in the inflamed tissues or tumor environment. A high concentration of ATP activates P2X7, a purinergic receptor, and induces the formation of a… read more here.
Keywords: cell lysis; ptdser; p2x7; vps13a ... See more keywords