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   Articles with "p2x7" as a keyword



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P2X7-mediated ATP secretion is accompanied by depletion of cytosolic ATP

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recommendations! Published in 2019 at "Purinergic Signalling"

DOI: 10.1007/s11302-019-09654-5

Abstract: ATP and its metabolites are important extracellular signal transmitters acting on purinergic P2 and P1 receptors. Most cells can actively secrete ATP in response to a variety of external stimuli such as gating of the… read more here.

Keywords: mediated atp; atp; p2x7 mediated; p2x7 ... See more keywords
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Full-Length P2X7 Structures Reveal How Palmitoylation Prevents Channel Desensitization

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recommendations! Published in 2019 at "Cell"

DOI: 10.1016/j.cell.2019.09.017

Abstract: P2X receptors are trimeric, non-selective cation channels activated by extracellular ATP. The P2X7 receptor subtype is a pharmacological target because of involvement in apoptotic, inflammatory, and tumor progression pathways. It is the most structurally and… read more here.

Keywords: full length; p2x7; structures reveal; receptor ... See more keywords
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Novel biologics targeting the P2X7 ion channel.

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recommendations! Published in 2019 at "Current opinion in pharmacology"

DOI: 10.1016/j.coph.2019.03.001

Abstract: Targeting the P2X7 ion channel, a danger sensor for extracellular nucleotides, improves outcomes in models of inflammation, cancer, and brain-diseases. Antibodies and nanobodies have been developed that antagonize or potentiate gating of P2X7. Their potential… read more here.

Keywords: p2x7; p2x7 ion; targeting p2x7; ion channel ... See more keywords

Inhibition of P2X7 receptor delays the progression of diabetic nephropathy and represses klotho expression

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recommendations! Published in 2018 at "Free Radical Biology and Medicine"

DOI: 10.1016/j.freeradbiomed.2018.10.093

Abstract: Introduction Previous studies in our laboratory have suggested that P2X7 could contribute to the progression of diabetic nephropathy and modulate klotho expression. Aim of this study was to investigate the role of P2X7 knockdown in… read more here.

Keywords: p2x7; progression diabetic; diabetic nephropathy; klotho expression ... See more keywords
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Longitudinal Positron Emission Tomography Imaging with P2X7 Receptor-Specific Radioligand 18F-FTTM in a Kainic Acid Rat Model of Temporal Lobe Epilepsy.

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recommendations! Published in 2022 at "ACS chemical neuroscience"

DOI: 10.1021/acschemneuro.2c00557

Abstract: P2X7 receptors (P2X7R), as a brain inflammation biomarker, play important roles in the epileptogenic progress. Mounting evidence supports their activation in the brain during epilepsy, and inhibition of the P2X7 receptor reduces the seizure frequency… read more here.

Keywords: p2x7 receptor; rat; p2x7; 18f fttm ... See more keywords
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Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology

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recommendations! Published in 2020 at "Molecular Psychiatry"

DOI: 10.1038/s41380-020-00965-3

Abstract: Scientists and health professionals are exhaustively trying to contain the coronavirus disease 2019 (COVID-19) pandemic by elucidating viral invasion mechanisms, possible drugs to prevent viral infection/replication, and health cares to minimize individual exposure. Although neurological… read more here.

Keywords: p2x7; hyperactivation p2x7; infection; p2x7 receptors ... See more keywords
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P2X7 receptor inhibition ameliorates dendritic spine pathology and social behavioral deficits in Rett syndrome mice

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recommendations! Published in 2020 at "Nature Communications"

DOI: 10.1038/s41467-020-15590-5

Abstract: Dysregulated immunity has been implicated in the pathogenesis of neurodevelopmental disorders but its contribution to synaptic and behavioral deficits in Rett syndrome (RTT) remains unknown. P2X7 receptors (P2X7Rs) are unique purinergic receptors with pro-inflammatory functions.… read more here.

Keywords: behavioral deficits; dendritic spine; p2x7; rett syndrome ... See more keywords
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Requirement of Xk and Vps13a for the P2X7-mediated phospholipid scrambling and cell lysis in mouse T cells

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recommendations! Published in 2022 at "Proceedings of the National Academy of Sciences of the United States of America"

DOI: 10.1073/pnas.2119286119

Abstract: Significance The extracellular concentration of adenosine triphosphate (ATP) reaches several hundred micromoles in the inflamed tissues or tumor environment. A high concentration of ATP activates P2X7, a purinergic receptor, and induces the formation of a… read more here.

Keywords: cell lysis; ptdser; p2x7; vps13a ... See more keywords
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P2X3-P2X7 SNPs and gene-gene and gene-environment interactions on pediatric asthma

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recommendations! Published in 2022 at "Journal of Asthma"

DOI: 10.1080/02770903.2022.2155184

Abstract: Abstract Background To investigate the relationship between polymorphisms of P2X3, P2X7 genes and environment interaction with susceptibility of childhood asthma. Methods We conducted a matched case-control study with 170 cases and 175 healthy controls. The… read more here.

Keywords: environment; gene gene; p2x3; asthma ... See more keywords
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Atheroprone flow activates inflammation via endothelial ATP-dependent P2X7-p38 signalling

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recommendations! Published in 2018 at "Cardiovascular Research"

DOI: 10.1093/cvr/cvx213

Abstract: Abstract Objective Atherosclerosis is a focal disease occurring at arterial sites of disturbed blood flow that generates low oscillating shear stress. Endothelial inflammatory signalling is enhanced at sites of disturbed flow via mechanisms that are… read more here.

Keywords: atheroprone; atheroprone flow; p2x7; flow activates ... See more keywords
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211. A NOVEL P2X7 KNOCKOUT RAT IS NOT PROTECTED FROM EXPERIMENTAL GLOMERULONEPHRITIS OR VASCULITIS

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recommendations! Published in 2019 at "Rheumatology"

DOI: 10.1093/rheumatology/kez061.026

Abstract: P2X7 is an ionotropic receptor activated by extracellular ATP which is expressed on immune cells including macrophages, dendritic cells and lymphocytes and is up-regulated on non-immune cells following injury. P2X7 has previously been shown to… read more here.

Keywords: p2x7; glomerulonephritis; novel p2x7; knockout rat ... See more keywords